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Eur J Cardiothorac Surg 2007;32:215-219. doi:10.1016/j.ejcts.2007.04.023
Copyright © 2007, European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved

Long-term follow-up and quality of life after closure of ventricular septal defect in adults

^a Department of Cardiothoracic Surgery, Thoraxcentre, Erasmus MC University Hospital, Rotterdam, The Netherlands
^b Department of Cardiology, Thoraxcentre, Erasmus MC University Hospital, Rotterdam, The Netherlands

Received 16 January 2007; received in revised form 13 April 2007; accepted 16 April 2007.

^_* Corresponding author. Address: Department of Cardiothoracic Surgery, Thoraxcentre, Bd 569, Erasmus MC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. Tel.: +31 10 4635411; fax: +31 10 4633993. (Email: g.bolraap{at}erasmusmc.nl).

Objective: To study patients who underwent surgical closure of a congenital ventricular septal defect (VSD) and presenting at adult age. Methods and results: A retrospective study was carried out of 28 patients (15 male) operated upon between 1980 and 2004. Patients were investigated by echocardiography, ECG and assessed for quality of life by a questionnaire. The indication for surgery was volume overload in 11 patients, endocarditis in 8, aortic valve regurgitation in 8 and the combination of a VSD with subvalvular aortic stenosis in 1. Follow-up was complete with a mean duration of follow-up of 13 years. There was no early or late mortality. One patient was reoperated for recurrent VSD. Twenty-five patients underwent echocardiography, which revealed a trivial residual VSD in two and mild aortic regurgitation in 10 (40%) patients. One patient was in atrial fibrillation. Health related quality of life in the dimensions cognitive functioning and sleep differed significantly from that of the general population. Conclusion: With a relative difference in indications for closure of a VSD in adulthood, surgical closure of VSD at adult age is an adequate and safe procedure, with good results on long-term follow-up. Progression of aortic valve regurgitation is a matter of concern.

Key Words: Ventricular septal defect • Surgical closure • Adult

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