HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Hao Zhang Bernard Park Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Amar, D. Articles by Thaler, H. T. Search for Related Content PubMed PubMed Citation Articles by Amar, D. Articles by Thaler, H. T. Related Collections Lung - cancer

Eur J Cardiothorac Surg 2007;32:431-434. doi:10.1016/j.ejcts.2007.06.017
Copyright © 2007, European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved

Inflammation and outcome after general thoracic surgery

^a Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY, United States
^b Department of Surgery, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY, United States
^c Department of Clinical Laboratories, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY, United States
^d Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY, United States

Received 19 April 2007; received in revised form 14 June 2007; accepted 18 June 2007.

^_* Corresponding author. Address: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, M-304, New York, NY 10021, United States. Tel.: +1 212 639 6798; fax: +1 212 772 8646. (Email: amard{at}mskcc.org).

Objective: To determine whether preoperative inflammation predisposes to major postoperative complications (PC) and poor outcome. Methods: Prospective data collection of 153 consecutive patients aged 73 ± 6 years scheduled for lung resection at a tertiary cancer center. High sensitivity C-reactive protein (CRP) and interleukin (IL)-6 levels were measured before surgery, on arrival to the postanesthesia care unit, and on the first morning after surgery. Results: PC occurred in 9/153 (5.9%) patients. In comparison to patients without PC, those with PC had a greater history of hypertension (P = 0.047), higher frequency of non-steroidal anti-inflammatory drug use (P = 0.007) and had a lower preoperative albumin level, 3.75 ± 0.65 g/dl versus 4.28 ± 0.33 g/dl, P = 0.03. Receiver operating characteristic analysis demonstrated a strong association between PC and preoperative CRP (area under the curve of 0.86), albumin (area under the curve of 0.86) and less so for IL-6 (area under the curve of 0.79). Conclusions: Markers of inflammation, CRP and IL-6, can help distinguish patients who are at high risk for major PC. These preliminary and novel data suggest that in addition to low albumin, a previously described marker of outcome, systemic inflammation is likely to be important in the pathogenesis of important PC.

Key Words: Albumin • C-reactive protein • Interleukin-6

This article has been cited by other articles:

				S. Paul, N. K. Altorki, S. Sheng, P. C. Lee, D. H. Harpole, M. W. Onaitis, B. M. Stiles, J. L. Port, and T. A. D'Amico Thoracoscopic lobectomy is associated with lower morbidity than open lobectomy: A propensity-matched analysis from the STS database J. Thorac. Cardiovasc. Surg., February 1, 2010; 139(2): 366 - 378. [Abstract] [Full Text] [PDF]

				M. K. Ferguson, J. Siddique, and T. Karrison Modeling major lung resection outcomes using classification trees and multiple imputation techniques Eur. J. Cardiothorac. Surg., November 1, 2008; 34(5): 1085 - 1089. [Abstract] [Full Text] [PDF]

				L. Paleari, P. Russo, A. Cesario, and P. Granone Inflammation and thoracic surgery: a complex interaction Eur. J. Cardiothorac. Surg., December 1, 2007; 32(6): 950 - 950. [Full Text] [PDF]