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Eur J Cardiothorac Surg 2007;32:696-701. doi:10.1016/j.ejcts.2007.07.029
Copyright © 2007, European Association for Cardio-thoracic Surgery. Published by Elsevier. All rights reserved.
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Sanjay Asopa
Sunil K. Ohri
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Review

Non-bacterial thrombotic endocarditis

Sanjay Asopa, Anish Patel, Omar A. Khan, Rajan Sharma, Sunil K. Ohri*

Wessex Cardiac Centre, Southampton General Hospital, Southampton, United Kingdom

Received 25 February 2007; received in revised form 26 June 2007; accepted 2 July 2007.

* Corresponding author. Address: Wessex Cardiothoracic Centre, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom. Tel.: +44 2380796233; fax: +44 2380798508. (Email: sunil{at}ohri.ac.uk).

Non-bacterial thrombotic endocarditis (NBTE) is a disease characterised by the presence of vegetations on cardiac valves, which consist of fibrin and platelet aggregates and devoid of inflammation or bacteria. NBTE has increasingly been recognised as a condition associated with numerous diseases and a potentially life-threatening source of thromboembolism. NBTE is not a common entity; however it is frequently underestimated, probably due to underlying diseases (cancer, autoimmune disorders, HIV). NBTE is difficult to diagnose and relies on strong clinical suspicion. NBTE is also difficult to manage and each case should be individually managed by identifying and treating the underlying pathology. Surgical intervention is not recommended unless the patient is in acute congestive failure.

Key Words: Marantic endocarditis • Carcinomatosis • Hypoxia • Infective endocarditis






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Copyright © 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.