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Eur J Cardiothorac Surg 2007;32:730-734. doi:10.1016/j.ejcts.2007.06.046
Copyright © 2007, European Association for Cardio-thoracic Surgery. Published by Elsevier. All rights reserved.
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Elastomeric surgical sealant for hemostasis of cardiovascular anastomosis under full heparinization

Masataka Etoa, Shigeki Moritaa,*, Masakazu Sugiurac, Tetsuji Yoshimurac, Ryuji Tominagaa, Takehisa Matsudab

a Division of Cardiovascular Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan
b Division of Biomedical Engineering, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan
c Sanyo Chemical Industries, Ltd., Kyoto 605-0995, Japan

Received 22 April 2007; received in revised form 18 June 2007; accepted 25 June 2007.

* Corresponding author. Address: Department of Cardiovascular Surgery, Kyushu Medical Center, National Hospital Organization, 1-8-1 Jigyohama, Chuo-ku, Fukuoka 810-8563, Japan. Tel.: +81 92 852 0700; fax: +81 92 847 8802. (Email: morita{at}kyumed.jp).

Purpose: We developed a novel surgical sealant, a viscous diisocyanated prepolymer, applicable to arterial hemostasis. The purpose of this study is to evaluate hemostatic effect of this surgical sealant under heparinized conditions. Methods: The effectiveness of this sealant was verified by applying it to the end-to-end anastomosis of canine carotid arteries. Five mongrel dogs were used. After a complete heparinization, the carotid arteries were clamped, divided, and end-to-end anastomoses were performed with four simple interrupted sutures. The sealant was coated on the anastomosis. After 5 min the clamps were removed and the hemostatic effect was evaluated. Three dogs were immediately subjected to macroscopic evaluation. Two dogs were subjected to angiography after 3 months and 16 months, respectively. Results: No bleeding occurred in any of the anastomoses immediately after the removal of the clamp. Macroscopic finding revealed no leakage of the sealant into the lumen. Carotid angiography revealed patent anastomoses without stenosis. Conclusion: A novel surgical sealant exhibited rapid and potent hemostatic effect on a moisturized tissue under full heparinization.

Key Words: Vascular anastomosis • Carotid artery • Surgical sealant






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Copyright © 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.