EJCTS Click here to go to Edwards website
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Eur J Cardiothorac Surg 2008;33:516-517. doi:10.1016/j.ejcts.2007.12.026
Copyright © 2008, European Association for Cardio-thoracic Surgery. Published by Elsevier. All rights reserved.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Ralph Alexander Schmid
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fahrner, R.
Right arrow Articles by Schmid, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fahrner, R.
Right arrow Articles by Schmid, R. A.
Related Collections
Right arrow Mediastinum

Case reports

Langerhans cell histiocytosis as differential diagnosis of a mediastinal tumor

René Fahrner, Beatrix Hoksch, Mathias Gugger, Ralph Alexander Schmid*

Division of Thoracic Surgery, University Hospital Bern, Switzerland

Received 17 September 2007; received in revised form 7 December 2007; accepted 10 December 2007.

* Corresponding author. Address: Division of Thoracic Surgery, Inselspital Bern, 3010 Bern, Switzerland. Tel.: +41 31 6322330; fax: +41 31 6322327. (Email: ralph.schmid{at}insel.ch).

We describe the case of a 55-year-old man who presented with parasternal swelling. The chest CT scan showed a large tumor of the chest wall infiltrating the subcutaneous tissue. To assume histologic diagnosis an open biopsy was performed. Between the myofibrils a coarse, white tumor with infiltrative growth was noted. Histopathologic examination revealed expanded atrophic skeletal muscle that was infiltrated by histiocytic cells. Numerous eosinophilic granulocytes and lymphocytes CD20 and CD3 positive could be detected and immunohistochemical staining was also positive for S-100 proteins and CD1a. Histologic findings were characteristic of Langerhans cell histiocytosis (LCH). To the best of our knowledge a LCH originating from the mediastinum in an adult as presented has not been previously described.

Key Words: Langerhans cell histiocytosis • Mediastinum • Tumor






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.