HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Luca Salvatore De Santo Giuseppe Santarpino Gianpaolo Romano Marisa De Feo Michelangelo Scardone Maurizio Cotrufo Permission Requests Google Scholar Articles by De Santo, L. S. Articles by Cotrufo, M. PubMed Articles by De Santo, L. S. Articles by Cotrufo, M. Related Collections Cardiac - other Transplantation - heart

Microbiologically documented nosocomial infections after cardiac surgery: an 18-month prospective tertiary care centre report

^a Chair of Cardiac Surgery, University of Foggia, Foggia, Italy
^b Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy
^c Department of Cardiovascular Surgery and Transplants, Monaldi Hospital, Naples, Italy

Received 3 September 2007; received in revised form 27 December 2007; accepted 27 December 2007.

^_* Corresponding author. Address: Viale Colli Aminei 491, 80131 Naples, Italy. Tel.: +39 081 5922118; fax: +39 081 5464594. (Email: luca.desanto{at}ospedalemonaldi.it; l.desanto{at}unifg.it).

Objective: The aim of this study was to prospectively evaluate frequency, characteristics, and predictors of nosocomial infections (NI) in a tertiary care centre. Methods: Study population included 925 patients (mean age 62.3 ± 12.5, 32.3% females, 22.9% diabetics, 6.8% with previous cardiac procedures) operated on between June 2005 and December 2006 (CABG 48.72%, valvular procedures 30.05%, thoracic aortic 10.9%, heart transplantations 3.78% and miscellanea 6.55%, procedure status: elective 72.9%, urgent 15.9% and emergent 11.2%). The study population was divided in two groups according to development of NI. Primary endpoints were multiorgan failure (MOF) and hospital mortality in the two groups. Secondary endpoints were length of intubation, intensive care unit (ICU) stay and overall hospitalisation. Univariate and multivariate analysis of NI predictors was conducted between 115 perioperative variables. Results: Eighty-three patients (9%) developed a NI. Infections affected respiratory tract in 51.8%, blood stream in 20.5 and wound infection in 27.7 (13.3% deep wound). Staphylococcal species (60.6%) predominated in blood stream and surgical wound infections while Gram-negative species predominated in respiratory infections. Patients affected by NI experienced significantly higher incidence of MOF (12% vs 0.8%) and hospital mortality (24.1 vs 6.9%). Development of NI significantly lengthened all the steps of postoperative process of care (length of intubation: 49.9 ± 73 h vs 19.1 ± 35.2; ICU stay: 10.4 ± 12.8 days vs 3.4 ± 4.6 and hospitalisation 20.7 ± 15.3 vs 10.6 ± 7). Independent predictors of NI were immunosuppressive therapy [OR 12.9 (CI 5.07–31.2)], reintubation [OR 10.3 (CI 4.6–2.3)], stroke [OR 9.5 (CI 1.8–49)], resternotomy for bleeding [OR 6.7 (CI 1.9–23.6)], emergent/urgent status [OR 3.6 (CI 1.5–8.4)], CVVH [OR 3.2 (CI 1.4–7.5)] and length of intubation [OR 1.03 (CI 1.01–1.1)]. Conclusions: NI still represents a serious complication. Presence of identified determinants of NI should prompt modification of management algorithms.

Key Words: Cardiac surgery • Postoperative complications • Nosocomial infections • Outcomes • Risk factors