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Functional and haemodynamic outcome 1 year after pulmonary thromboendarterectomy

Papworth Hospital, Papworth Everard, Cambridge CB23 3RE, UK

Received 3 September 2007; received in revised form 7 April 2008; accepted 8 April 2008.

^_* Corresponding author. Tel.: +44 1480 364806; fax: +44 1480 364709. (Email: david.jenkins{at}papworth.nhs.uk).

Objective: Chronic thromboembolic pulmonary hypertension (CTEPH) results in severe symptoms and impaired survival. Pulmonary thromboendarterectomy (PTE) is considered the gold standard treatment. Many units have reported excellent early results post PTE, but there is less information on whether benefit is sustained. We sought to determine the medium-term functional and haemodynamic outcome for patients following PTE and the longer-term survival after discharge from hospital. Methods: Data were collected prospectively on all patients who underwent PTE in the UK between 1997 and June 2006. Patients were reassessed at 3 and 12 months after operation. Follow-up over time was assessed using repeated measures ANOVA, the Friedman test or Wilcoxon signed ranks test as appropriate. Results: Two hundred and twenty-nine patients underwent PTE, survived to hospital discharge, and completed follow-up. At 3 months following operation, there was a significant reduction in mean pulmonary artery pressure (47 ± 14 to 25 ± 14 mmHg, p < 0.001), a significant increase in cardiac index (1.9 ± 0.7 to 2.5 ± 0.6 l/min m², p < 0.001) and a significant increase in 6-min walk distance (269 ± 123 to 375 ± 104 m, p < 0.001). At 12-month follow-up, the haemodynamic improvements were sustained and there was a further increase in 6-min walk distance (375 ± 104 to 392 ± 108 m, p = 0.004). NYHA class was significantly reduced at 3 months, with the improvement sustained at 12 months. Conditional survival following discharge from hospital was 92.5% at 5 years and 88.3% at 10 years. Conclusions: PTE is a very effective therapy for CTEPH. This is the first report from a continuous national series to fully characterise haemodynamic and functional outcome 1 year after PTE. Patients enjoy continued improvement in haemodynamic status that translates into better exercise capacity, reduced symptoms and excellent survival.

Key Words: Pulmonary thromboendarterectomy • Pulmonary endarterectomy • Pulmonary hypertension • Survival • Surgical outcomes