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Eur J Cardiothorac Surg 2008;34:685-686. doi:10.1016/j.ejcts.2008.05.022
Copyright © 2008, European Association for Cardio-thoracic Surgery. Published by Elsevier. All rights reserved.

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Ravindranath Tiruvoipati
Giles J. Peek
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Case reports

Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygenation

Richard P. Chalwin, Ravindranath Tiruvoipati*, Giles J. Peek

Department of ECMO, Glenfield Hospital, Leicester, LE3 9QP, UK

Received 30 October 2007; received in revised form 14 April 2008; accepted 19 May 2008.

* Corresponding author. Address: Department of Intensive Care, Frankston Hospital, Frankston, Victoria 3199, Australia. Tel.: +61 431279347; fax: +61 397847398. (Email: travindranath{at}hotmail.com).

Bleeding remains a potential complication for patients requiring extracorporeal life support systems. Recombinant activated factor VII (rFVIIa) is one of the drugs used in controlling bleeding. Its use is generally found to be safe. We report a paediatric patient who developed fatal thrombosis with the use of rFVIIa whilst on extracorporeal membrane oxygenation and discuss the possible factors that lead to fatal thrombosis.

Key Words: Extracorporeal membrane oxygenation • Thrombosis • Bleeding




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S. Rubin, A. N. Ali, O. N. Pages, and B. Baehrel
How to replace an extracorporeal life support without interruption of the cardiopulmonary assistance
Interactive CardioVascular and Thoracic Surgery, August 1, 2009; 9(2): 311 - 313.
[Abstract] [Full Text] [PDF]




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Copyright © 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.