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Real-time adjustment of ventricular restraint therapy in heart failure

^a Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States
^b Division of Cardiac Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Received 23 March 2008; received in revised form 3 July 2008; accepted 4 July 2008.

^_* Corresponding author. Tel.: +1 617 732 7775; fax: +1 617 732 6559. (Email: fchen{at}partners.org).

Objective: Current ventricular restraint devices do not allow for either the measurement or adjustment of ventricular restraint level. Periodic adjustment of restraint level post-device implantation may improve therapeutic efficacy. We evaluated the feasibility of an adjustable quantitative ventricular restraint (QVR) technique utilizing a fluid-filled polyurethane epicardial balloon to measure and adjust restraint level post-implantation guided by physiologic parameters. Methods: QVR balloons were implanted in nine ovine with post-infarction dilated heart failure. Restraint level was defined by the maximum restraint pressure applied by the balloon to the epicardium at end-diastole. An access line connected the balloon lumen to a subcutaneous portacath to allow percutaneous access. Restraint level was adjusted while left ventricular (LV) end-diastolic volume (EDV) and cardiac output was assessed with simultaneous transthoracic echocardiography. Results: All nine ovine successfully underwent QVR balloon implantation. Post-implantation, restraint level could be measured percutaneously in real-time and dynamically adjusted by instillation and withdrawal of fluid from the balloon lumen. Using simultaneous echocardiography, restraint level could be adjusted based on LV EDV and cardiac output. After QVR therapy for 21 days, LV EDV decreased from 133 ± 15 ml to 113 ± 17 ml (p < 0.05). Conclusion: QVR permits real-time measurement and physiologic adjustment of ventricular restraint therapy after device implantation.

Key Words: Ventricular restraint • Heart failure • Cardiomyopathy • Surgery

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