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Clinical study of modified Ivor-Lewis esophagectomy plus adjuvant radiotherapy for local control of stage IIA squamous cell carcinoma in the mid-thoracic esophagus

Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, China

Received 13 June 2008; received in revised form 19 August 2008; accepted 1 September 2008.

^_* Corresponding author. Tel.: +86 531 8518 7884; fax: +86 531 8518 7893. (Email: wz620226{at}hotmail.com).

Objective: To control the postoperative local recurrence is one of the critical factors to improve prognosis of patients with esophageal carcinoma. The aim of this study is to evaluate the effectiveness of modified Ivor-Lewis esophagectomy plus adjuvant radiotherapy for local control of stage IIA squamous cell carcinoma in the mid-thoracic esophagus. Methods: One hundred and twenty-five patients with stage IIA mid-thoracic esophageal squamous cell carcinoma who underwent modified Ivor-Lewis esophagectomy between June 1999 and June 2002 were included in the retrospective analysis. All the patients were evaluated within 3 years after surgery to detect tumor recurrence. Kaplan–Meier method was used to calculate the survival rate and logistic regression analysis was performed to identify risk factors of locoregional recurrence. Results: The overall 3-year and 5-year survival rate in all patients was 58.4% and 43.2%, respectively. Tumor recurrence occurred in 61 patients (48.8%) within 3 years after operation. The median disease-free interval was 12.6 months. Thirty-three patients (26.4%) developed locoregional recurrence, 23 patients (18.4%) developed distant recurrence and 5 patients (4.0%) developed locoregional and distant recurrence simultaneously. Locoregional recurrence rate of patients with postoperative radiotherapy was significantly lower than that of those without postoperative radiotherapy (p < 0.05). Logistic regression analysis showed that adjuvant radiotherapy (p = 0.007) was an independent risk factor for tumor locoregional recurrence. Cox regression analysis showed that locoregional recurrence but not adjuvant radiotherapy was a relevant prognostic factor of patients with stage IIA esophageal cancer. Conclusions: Modified Ivor-Lewis esophagectomy with two-field lymph node dissection plus adjuvant radiotherapy might be an effective strategy to achieve local control of stage IIA mid-thoracic esophageal squamous cell carcinoma.

Key Words: Esophageal neoplasms • Ivor-Lewis esophagectomy • Neoplasm recurrence • Local • Radiotherapy

This article has been cited by other articles:

				G. Chen, Z. Wang, X.-y. Liu, and F.-y. Liu Adjuvant Radiotherapy After Modified Ivor-Lewis Esophagectomy: Can It Prevent Lymph Node Recurrence of the Mid-Thoracic Esophageal Carcinoma? Ann. Thorac. Surg., June 1, 2009; 87(6): 1697 - 1702. [Abstract] [Full Text] [PDF]