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Association of IL6 and IL10 with renal dysfunction and the use of haemofiltration during cardiopulmonary bypass

^a Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
^b Wythenshawe Hospital, Southmoor Road, Manchester, M23 9LT, UK

Received 18 November 2007; received in revised form 13 September 2008; accepted 14 October 2008.

^_* Corresponding author. Tel.: +44 1612766011; fax: +44 1612768522. (Email: eindara{at}yahoo.com).

Objective: Assessment of the effects of haemofiltration during cardiopulmonary bypass (CPB) in coronary artery bypass grafting (CABG) on the renal function and correlation with interleukin 6 (IL6) and interleukin 10 (IL10) levels. Methods: Seventy-nine patients scheduled for elective CABG were prospectively randomised into two groups. Group A with a haemofilter attached to arterial line of the CPB circuit and group B without a haemofilter. The two groups were comparable in their symptoms, sex, and previous history of myocardial infarction, left ventricular function, cross-clamp time, bypass time and total grafting per patients. Blood urea and creatinine levels were measured the day before operation, 12 h after operation and on the 3rd postoperative day. IL6 and IL10 were measured in blood samples collected 1 h before surgery, on arrival to ITU and after 12 h. IL6 and IL10 levels were measured using ELISA test. Results: High levels of IL6 (>100 pg/ml) postoperatively were associated with increased incidence of renal dysfunction (p < 0.017). Additionally, high IL10 (>30 pg/ml) levels postoperatively were associated with increased incidence of renal dysfunction (p < 0.014). There were no effects of the haemofilter on postoperative IL6 and IL10 levels. Use of haemofiltration during CPB was found not to be protective against renal dysfunction (p < 0.071). Conclusions: Haemofilter use during cardiopulmonary bypass does not have a protective effect on postoperative kidney function. Haemofilter has no effect on the level of IL6 and IL10.

Key Words: Haemofilter • Cardiopulmonary bypass • Cytokines