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Mitral valve surgery plus concomitant atrial fibrillation ablation is superior to mitral valve surgery alone with an intensive rhythm control strategy

^a University Hospital Wales, Cardiff, United Kingdom
^b Medtronic Bakken Research Center, Maastricht, The Netherlands

Received 29 August 2008; received in revised form 24 December 2008; accepted 26 December 2008.

^_* Corresponding author. Address: University Hospital of Wales, Cardiac Services Directorate, Heath Park, CF14 4XW Cardiff, United Kingdom. Tel.: +44 29 2074 2944; fax: +44 29 2074 5439. (Email: Uvonopp{at}CardiffandVale.wales.nhs.uk).

Objective: Prospective randomised study comparing patients with atrial fibrillation (AF) of more than 6 months duration after mitral valve surgery plus biatrial modified radiofrequency Maze procedure using Medtronic Cardioblate System (Cardioblate group, n = 24) vs mitral valve surgery plus intensive rhythm control strategy (control group, n = 25). Methods: Patients were blinded to randomisation. Preoperatively, at discharge, and at 3-month and 1-year follow-up, echocardiography, quality of life assessments and ECGs were done. In both groups, sinus rhythm (SR) restoration was attempted by intra- and postoperative DC cardioversion and class III antiarrhythmic medication. All patients received warfarin. Amiodarone and warfarin was considered for discontinuation after 3 months in SR, 24-h Holter or event monitor excluding AF. Results: Both groups underwent mitral valve replacement or repair (Cardioblate vs control: 16:8 vs 10:15), had similar gender (male: 33% vs 56%), age (66 ± 8 years vs 68 ± 9 years), additional aortic valve replacement (7 vs 6 patients), tricuspid annuloplasty (13 vs 13 patients), and CABG (10 vs 16 patients). There was 0% operative mortality, 0% postoperative cerebrovascular accidents, but 2 late deaths in the control group. At discharge, 3- and 12-month follow-up, more patients in the Cardioblate group returned to normal SR compared to control (29%, 57% and 75% vs 20%, 43% and 39%; p = 0.030). Return of functional atrial contraction in patients in SR at 1 year was comparable between groups (63% vs 89%, NS), and more likely in non-rheumatic pathology and preoperative AF of shorter duration. The effectiveness of atrial contraction was 36 ± 14% vs 43 ± 18% of transmitral flow and there was no difference between groups. Amiodarone treatment decreased more in Cardioblate group over time (92%, 55% and 29% vs 52%, 52% and 21%; p = 0.003), whereas warfarin decrease was comparable (100%, 100% and 71% vs 100%, 95% and 82%; NS). Conclusions: Radiofrequency Maze ablation additional to mitral valve surgery resulted in a higher SR conversion rate (75%), despite control group treatment with intensive rhythm control strategy having a higher SR conversion rate (39%) compared to literature (25%). Maze ablation resulted in normalisation of atrial function in 63% of patients converted to SR.

Key Words: Cardiac surgery • Mitral valve • Atrial fibrillation • Radiofrequency ablation • Rhythm control

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