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A review of the lung transplantation programme in Ireland 2005–2007

National Centre for Cardiothoracic Surgery, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland

Received 14 May 2008; received in revised form 29 September 2008; accepted 2 October 2008.

^_* Corresponding author. Tel.: +353 18034485; fax: +353 18034866. (Email: aewood{at}mater.ie).

Objective: Lung transplantation is a recognised surgical option for patients with end stage respiratory disease. We present data relating to the initiation of the Irish lung transplant programme in 2005. Methods: Seventeen patients: 7 male and 10 female have undergone lung transplantation. The indications for lung transplantation included COPD (n = 8), idiopathic pulmonary fibrosis (n = 5), bronchiolitis obliterans (n = 2), lymphangioleiomyomatosis (n = 1), and cystic fibrosis (n = 1). Eleven single lungs transplants were completed, while six patients underwent double sequential lung transplantation. The immunosuppression regimen included basiliximab as induction therapy, with steroids, mycophenolate mofetil nd cyclosporine or tacrolimus. Results: The operative mortality was zero. One patient died at 10 months post double lung transplantation secondary to bronchiolitis obliterans. Primary graft dysfunction was observed in two patients who required ventilatory support for 3 and 5 days respectively. Acute cellular rejection was observed in four patients (grade A2 n = 3, grade A3 n = 2). The cumulative 1-year survival was 94.1%, which compares favourably to an international standard of 78%. Conclusions: The initiation of a lung transplant programme in Ireland has been successfully undertaken and initially provided results comparable to established lung transplant programs.

Key Words: Lung transplantation • End stage respiratory disease • Immunosuppression