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Review

Inherited diseases and syndromes leading to aortic aneurysms and dissections

^a Kayseri Education and Research Hospital, Department of Medical Genetics, 38010, Kayseri, Turkey
^b Erciyes University, Medical Faculty, Department of Medical Genetics, Kayseri, Turkey

Received 8 October 2008; received in revised form 6 January 2009; accepted 7 January 2009.

^_* Corresponding author. Address: Bahcelievler Street, Erdener Appartment No: 6/23, 38280, Talas, Kayseri, Turkey. Tel.: +90 535 584 7978; fax: +90 352 320 7313. (Email: aocaglayan{at}erciyes.edu.tr).

Genes affect virtually all human characteristics and diseases. These influences can be ascertained in individual patients through a review of the family history, physical examination and the use of medical diagnostics. Aneurysms and dissections are a leading cause of morbidity and mortality, in addition to medical expense, and, on the whole, their specific molecular mechanisms are beginning to be identified. Over the past decade, genetic tests have become available for numerous heritable disorders especially inherited with mendelian models. An important fact is that the results of genetic tests may also be useful beyond the individual affected by the genetic disorder. Depending upon the disorder, knowledge of carrier status may be important. Because of these facts, some essential information regarding basic genetics of aneurysm and dissection has been presented in this study.

Key Words: Aneurysms • Dissections • Genetics