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Review

Endogenous stem cells in patients undergoing coronary artery bypass graft surgery

Department of Cardiothoracic Surgery, Cardiac and Vascular Sciences, St. George's Hospital, University of London, London, UK

Received 6 March 2009; received in revised form 6 March 2009; accepted 3 April 2009.

^_* Corresponding author. Address: Department of Cardiac Surgery, St. George's Hospital, Blackshaw Road, London, UK. Tel.: +44 (0) 20 87253565; fax: +44 (0) 20 87252049. (Email: marjan.jahangiri{at}stgeorges.nhs.uk).

Considerable research efforts have recently been made towards the application of autologous stem cell therapy for cardiovascular regeneration. Patients with coronary artery disease undergoing surgery represent a potential target. As yet, this approach has failed to obtain satisfactory evidence in clinical studies. However, several observational studies have described mobilising effect of cardiac surgery on endogenous stem cells, although the mechanisms of this phenomenon and its clinical relevance are not defined. This article reviews available clinical data on the effect of cardiac surgery on endogenous stem cells and outlines some of the controversies in this area.

Key Words: Stem cells • Coronary artery bypass graft surgery • Coronary artery disease