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Reviews

Gene therapies for pulmonary hypertension—from experimental trials to bedside aspects

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China

Received 28 November 2008; received in revised form 9 June 2009; accepted 29 June 2009.

^_* Corresponding author. Tel.: +86 27 857 26754; fax: +86 27 857 26821. (Email: menglk{at}126.com; liuchengxh{at}yahoo.com.cn).

Accompanying the continuously deepening understanding of the mechanism of pulmonary hypertension that many genes are found to be aetiologically involved in its development, burgeoning literature manifest that gene therapies aimed at correcting these genetic defects have the ability to restore deficient pulmonary gene expression, over-express biologically active gene products, reverse established disease and regenerate pulmonary vasculature, and may constitute a promising therapeutic strategy for pulmonary hypertension. Therefore, to provide new information to basic scientists and clinical investigators, we present a review that attempts a clear description of the therapeutic potential of gene therapy in the treatment of pulmonary hypertension.

Key Words: Pulmonary hypertension • Gene transfer • Gene therapy