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European Journal of Cardio-Thoracic Surgery, Vol 4, 556-560, Copyright © 1990 by European Association for Cardio-thoracic Surgery
M Turri, G Thiene, U Bortolotti, A Milano, A Mazzucco and V Gallucci
A consecutive series of 602 surgically excised aortic valves was evaluated
by means of macroscopic and histological study. Pure aortic stenosis was
diagnosed in 140 patients, pure incompetence in 254 and combined
dysfunction in 208. Of the cases with pure aortic stenosis, 38% were
rheumatic, 34% were calcified bicuspid valves and 23% showed dystrophic
calcification. Half the patients with pure aortic regurgitation showed
aortic root dilatation. Most cases of combined aortic stenosis and
regurgitation were the sequelae of rheumatic fever. A male prevalence was
detectable in each group (mean male: female ratio = 2.6), and was highest
in infective endocarditis and aortic root dilatation. Infective
endocarditis was a frequent complication of congenitally bicuspid valves.
In conclusion, rheumatic disease is still a frequent cause for surgical
replacement of the aortic valve. At least half the explanted aortic valves
have degenerative or congenital diseases which are often the site of a
superimposed infective endocarditis.
ARTICLES
Surgical pathology of aortic valve disease. A study based on 602 specimens
Department of Pathology, University of Padua Medical School, Italy.
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