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European Journal of Cardio-Thoracic Surgery, Vol 4, 665-670, Copyright © 1990 by European Association for Cardio-thoracic Surgery
MJ Jurmann, L Dammenhayn, HJ Schaefers and A Haverich
Blood granulocyte-mediated reactions involving generation of oxygen-
derived free radicals have recently been shown to be capable of causing
injury to the lungs. These findings suggest a similar mechanism also to be
involved in the development of pulmonary ischemia/reperfusion injury. In
the present study, therefore, the effects of three oxygen- derived free
radical scavengers, superoxide dismutase (SOD; 1 mg/kg), catalase (20,000
IU/kg) and allopurinol (45 mg/kg), were evaluated during reperfusion in a
rabbit model after 2 h normothermic ischemia of the lung. During
reperfusion, ischemic lungs were found to have an elevated pulmonary
vascular resistance, increased total and extravascular lung water content,
and decreased arterial oxygen tension (PaO2) compared to control animals.
SOD and catalase, but not allopurinol, were able to reduce pulmonary injury
by lowering the pulmonary vascular resistance, but could not prevent
pulmonary damage as shown by total lung water (TLW) or PaO2. It is
concluded that oxygen- derived free radicals such as hydrogen peroxide and
the superoxide anion may play an important role in precipitating pulmonary
injury after ischemia. The failure of xanthine oxidase inhibition
(allopurinol) to exert protective effects may suggest that oxygen- derived
free radical generation following pulmonary ischemia occurs predominantly
via leukocyte-mediated reactions.
ARTICLES
Pulmonary reperfusion injury: evidence for oxygen-derived free radical mediated damage and effects of different free radical scavengers
Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, FRG.
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