| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
European Journal of Cardio-Thoracic Surgery, Vol 5, 628-634, Copyright © 1991 by European Association for Cardio-thoracic Surgery
RA Hopkins, C Bull, SG Haworth, MR de Leval and J Stark
In this clinical study, 20 high risk infants and neonates were monitored to
identify and characterize pulmonary hypertensive crises following surgery
for congenital cardiac defects. Monitoring included right ventricular or
pulmonary artery pressure catheters and transcutaneous oximetry. Eleven
patients also had continuous analog recording of hemodynamic data so that
antecedents of crises and the sequence of events following treatment could
be reconstructed. Eleven of the 20 patients had one or more crises. Six of
these ultimately died whereas 5 patients survived with aggressive
vasodilator therapy. Four patients without crises but with episodic
pulmonary hypertension benefitted from pulmonary vasodilator therapy to
ease weaning from ventilatory support. Typically, each crisis was
associated with a stress event. Crises were difficult to ablate if not
rapidly treated and multiple crises would often cluster following an
initial event. High dose narcotic (fentanyl) analgesia was found to be
important in the postoperative management. Tolazoline and oxygen were the
most consistently useful vasodilators, but isoproterenol and nitrates also
played a role. Five of the children who died were examined post mortem:
histologically, there was increased pulmonary arterial muscularization in
2, in none were there changes of fixed pulmonary vascular disease. The
postoperative management must be individualized on the basis of monitored
responses of pulmonary circulation.
ARTICLES
Pulmonary hypertensive crises following surgery for congenital heart defects in young children
Thoracic Unit, Hospital for Sick Children, London, England, UK.
This article has been cited by other articles:
|
|
 |
|
  D. Wenzel, R. Knies, M. Matthey, A. M. Klein, J. Welschoff, V. Stolle, P. Sasse, W. Roll, J. Breuer, and B. K. Fleischmann {beta}2-Adrenoceptor Antagonist ICI 118,551 Decreases Pulmonary Vascular Tone in Mice via a Gi/o Protein/Nitric Oxide-Coupled Pathway Hypertension, July 1, 2009; 54(1): 157 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Urdaneta, E. Lobato, T Beaver, J. Muehlschlegel, D. Kirby, C Klodell, and A Sidi Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog Perfusion, March 1, 2008; 23(2): 117 - 125. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Lahm, K. M. Patel, P. R. Crisostomo, T. A. Markel, M. Wang, C. Herring, and D. R. Meldrum Endogenous estrogen attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction: the effects of sex and menstrual cycle Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E865 - E871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhang, S. Wu, J. Liang, G. Zhang, G. Jiang, M. Zhou, and X. Li Unidirectional Monovalve Homologous Aortic Patch for Repair of Ventricular Septal Defect With Pulmonary Hypertension Ann. Thorac. Surg., June 1, 2007; 83(6): 2176 - 2181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Journois, C. Baufreton, P. Mauriat, P. Pouard, P. Vouhe, and D. Safran Effects of Inhaled Nitric Oxide Administration on Early Postoperative Mortality in Patients Operated for Correction of Atrioventricular Canal Defects Chest, November 1, 2005; 128(5): 3537 - 3544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Tsai, M. Wang, M. W. Turrentine, Y. Mahomed, J. W. Brown, and D. R. Meldrum Hypoxic pulmonary vasoconstriction in cardiothoracic surgery: basic mechanisms to potential therapies Ann. Thorac. Surg., July 1, 2004; 78(1): 360 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ichinose, J. D. Roberts Jr, and W. M. Zapol Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential Circulation, June 29, 2004; 109(25): 3106 - 3111. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Widlitz and R.J. Barst Pulmonary arterial hypertension in children Eur. Respir. J., January 1, 2003; 21(1): 155 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Balzer, H. W. Kort, R. W. Day, H. M. Corneli, J. P. Kovalchin, B. C. Cannon, S. F. Kaine, D. D. Ivy, S. A. Webber, A. Rothman, et al. Inhaled Nitric Oxide as a Preoperative Test (INOP Test I): The INOP Test Study Group Circulation, September 24, 2002; 106(12_suppl_1): I-76 - I-81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lindberg, A. K. Olsson, P. Jogi, and C. Jonmarker How common is severe pulmonary hypertension after pediatric cardiac surgery? J. Thorac. Cardiovasc. Surg., June 1, 2002; 123(6): 1155 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Mignosa, V. Duca, I. Bianca, D. Salvo, G. Ferlazzo, and M. Abbate Fenestrated arterial switch operation: surgical approach to an unusual transposition of the great arteries complex Ann. Thorac. Surg., May 1, 2001; 71(5): 1684 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Schulze-Neick, D J Penny, G P Derrick, R Dhillon, M L Rigby, A Kelleher, A Bush, and A N Redington Pulmonary vascular-bronchial interactions: acute reduction in pulmonary blood flow alters lung mechanics Heart, September 1, 2000; 84(3): 284 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Day, J. A. Hawkins, E. C. McGough, K. L. Crezee, and G. S. Orsmond Randomized controlled study of inhaled nitric oxide after operation for congenital heart disease Ann. Thorac. Surg., June 1, 2000; 69(6): 1907 - 1912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Carteaux, S. Roux, M. Siaghy, B. Schjoth, P. Dolofon, Y. Bechamps, P. M. Mertes, and J.-P. Villemot Acute pulmonary hypertension after cardiopulmonary bypass in pig: the role of endogenous endothelin Eur. J. Cardiothorac. Surg., March 1, 1999; 15(3): 346 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Muralidhar and D. P. Shetty Technique to Monitor Pulmonary Artery Pressure After Pediatric Cardiac Surgery Asian Cardiovasc Thorac Ann, December 1, 1998; 6(4): 295 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Vitvitsky, J. P. Griffin, M. H. Collins, T. L. Spray, and J. W. Gaynor Increased pulmonary blood flow produces endothelial cell dysfunction in neonatal swine Ann. Thorac. Surg., October 1, 1998; 66(4): 1372 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Bando, P. Vijay, M. W. Turrentine, T. G. Sharp, L. J. Means, G. J. Ensing, B. J. Lalone, Y. Sekine, L. Szekely, and J. W. Brown Dilutional And Modified Ultrafiltration Reduces Pulmonary Hypertension After Operations For Congenital Heart Disease: A Prospective Randomized Study J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 517 - 527. [Abstract] [Full Text]
|
|
|
|
|
|
M I Turanlahti, P O Laitinen, S J Sarna, and E Pesonen Nitric oxide, oxygen, and prostacyclin in children with pulmonary hypertension Heart, February 1, 1998; 79(2): 169 - 174. [Abstract] [Full Text]
|
|
|
|
|
|
A. Gamillscheg, G. Zobel, B. Urlesberger, J. Berger, D. Dacar, J. I. Stein, B. Rigler, H. Metzler, and A. Beitzke INHALED NITRIC OXIDE IN PATIENTS WITH CRITICAL PULMONARY PERFUSION AFTER FONTAN-TYPE PROCEDURES AND BIDIRECTIONAL GLENN ANASTOMOSIS J. Thorac. Cardiovasc. Surg., March 1, 1997; 113(3): 435 - 442. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Myers, J. J. Wizorek, A. K. Myers, M. O'Donoghue, M. T. Pettit, P. C. Kouretas, H. J. Dalton, Y. Wang, and R. A. Hopkins MATURATION ALTERS THE PULMONARY ARTERIAL RESPONSE TO HYPOXIA AND INHALED NITRIC OXIDE IN THE PRESENCE OF ENDOTHELIAL DYSFUNCTION J. Thorac. Cardiovasc. Surg., February 1, 1997; 113(2): 270 - 277. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Myers, J. J. Wizorek, A. K. Myers, E. Yankah, M. T. Pettit, P. C. Kouretas, H. J. Dalton, Y. Wang, and R. A. Hopkins Pulmonary Arterial Endothelial Dysfunction Potentiates Hypercapnic Vasoconstriction and Alters the Response to Inhaled Nitric Oxide Ann. Thorac. Surg., December 1, 1996; 62(6): 1677 - 1684. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Atz, I. Adatia, and D. L. Wessel Rebound Pulmonary Hypertension After Inhalation of Nitric Oxide Ann. Thorac. Surg., December 1, 1996; 62(6): 1759 - 1764. [Abstract] [Full Text]
|
|
|
|
|
|
K. Bando, M. W. Turrentine, T. G. Sharp, Y. Sekine, T. X. Aufiero, K. Sun, E. Sekine, and J. W. Brown PULMONARY HYPERTENSION AFTER OPERATIONS FOR CONGENITAL HEART DISEASE: ANALYSIS OF RISK FACTORS AND MANAGEMENT J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1600 - 1609. [Abstract] [Full Text]
|
|
|
|
|
|
A. P. Goldman, R. E. Delius, J. E. Deanfield, M. R. de Leval, P. E. Sigston, and D. J. Macrae Nitric Oxide Might Reduce the Need for Extracorporeal Support in Children With Critical Postoperative Pulmonary Hypertension Ann. Thorac. Surg., September 1, 1996; 62(3): 750 - 755. [Abstract] [Full Text]
|
|
|
|
|
|
C. Baufreton, D. Journois, F. Leca, W. Khoury, D. Tamisier, and P. Vouhe TEN-YEAR EXPERIENCE WITH SURGICAL TREATMENT OF PARTIAL ATRIOVENTRICULAR SEPTAL DEFECT: RISK FACTORS IN THE EARLY POSTOPERATIVE PERIOD J. Thorac. Cardiovasc. Surg., July 1, 1996; 112(1): 14 - 20. [Abstract] [Full Text]
|
|
|
|
|
|
M. Kadletz, R. J. Dignan, and A. S. Wechsler Reactivity to Alpha Agonists Is Heightened in Immature Porcine Pulmonary Arteries Ann. Thorac. Surg., May 1, 1996; 61(5): 1359 - 1362. [Abstract] [Full Text]
|
|
|
|
|
|
A. P. Goldman, R. E. Delius, J. E. Deanfield, and D. J. Macrae Nitric Oxide Is Superior to Prostacyclin for Pulmonary Hypertension After Cardiac Operations Ann. Thorac. Surg., August 1, 1995; 60(2): 300 - 305. [Abstract] [Full Text]
|
|
|
|
|
|
F. X. McGowan Jr., P. J. Davis, R. D. Siewers, and P. J. del Nido Coronary vasoconstriction mediated by endothelin-1 in neonates: Reversal by nitroglycerin J. Thorac. Cardiovasc. Surg., January 1, 1995; 109(1): 88 - 98. [Abstract] [Full Text]
|
|
|
|
|
|
O. I. Miller, D. S. Celermajer, J. E. Deanfield, and D. J. Macrae Very-low-dose inhaled nitric oxide: A selective pulmonary vasodilator after operations for congenital heart disease J. Thorac. Cardiovasc. Surg., September 1, 1994; 108(3): 487 - 494. [Abstract] [Full Text]
|
|
|
|
|
|
D. Journois, P. Pouard, P. Mauriat, T. Malhere, P. Vouhe, and D. Safran Inhaled nitric oxide as a therapy for pulmonary hypertension after operations for congenital heart defects J. Thorac. Cardiovasc. Surg., April 1, 1994; 107(4): 1129 - 1135. [Abstract] [Full Text]
|
|
|
|
|
|
H. Komai and S. G Haworth The effect of cardiopulmonary bypass on the lung: the injured pulmonary vascular endothelium Perfusion, January 1, 1993; 8(1): 55 - 62. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
