HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vouhe, P. R. Articles by Neveux, J. Y. Search for Related Content PubMed PubMed Citation Articles by Vouhe, P. R. Articles by Neveux, J. Y.

European Journal of Cardio-Thoracic Surgery, Vol 5, 176-180, Copyright © 1991 by European Association for Cardio-thoracic Surgery

ARTICLES

Heart transplantation in children: risk factors of early and late mortality

PR Vouhe, D Tamisier, F Leca, J Le Bidois, W Khoury, P Mauriat, P Pouard, D Sidi, J Kachaner and JY Neveux
Department of Cardiac Surgery, Hopital Laennec, Paris, France.

In order to identify predictive risk factors of poor outcome following heart transplantation in children, we performed a retrospective analysis of our pediatric recipient population: 31 children, aged 15 days to 15 years (mean = 5.2 +/- 4.9 years). The preoperative diagnosis was cardiomyopathy in 17 (55%), congenital heart disease in 13 (42%) and end-stage valvular disease in 1 (3%). There were 5 operative deaths: hyperacute rejection (2), low cardiac output syndrome (3); 4 in- hospital deaths: infection (2), multiorgan failure (2) and 4 late deaths: acute rejection (1), chronic rejection (1), lymphoma (1), unknown (1). The actuarial probability of survival (+/- SE) was 62% +/- 10% at 1 year and 53% +/- 12% at 2 years. Univariate analysis was used to evaluate the following risk factors: age, diagnosis, hemodynamic decompensation, previous cardiac surgery, ischemic time of the graft, technique of graft preservation, preoperative pulmonary artery pressure, occurrence of postoperative low cardiac output syndrome (LCOS) with pulmonary hypertension (PHT). The occurrence of early LCOS with PHT significantly increased both early and late mortality (78% early mortality, 100% overall mortality). This syndrome occurred in 9 patients (29%) and was attributed to primary graft failure in 2, increased pulmonary vascular resistances in 6 and multiple factors in 1. Although not significant, two factors may increase early survival: young age (less than or equal to 1 year) at operation and improved technique of graft preservation.

This article has been cited by other articles:

				A. C. Anyanwu, C. A. Rogers, and A. J. Murday A simple approach to risk stratification in adult heart transplantation Eur. J. Cardiothorac. Surg., October 1, 1999; 16(4): 424 - 428. [Abstract] [Full Text] [PDF]