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European Journal of Cardio-Thoracic Surgery, Vol 5, 466-472, Copyright © 1991 by European Association for Cardio-thoracic Surgery

ARTICLES

Diagnostic and therapeutic strategy in malignant pleural mesothelioma

D Branscheid, S Krysa, E Bauer, H Bulzebruck and J Schirren
Department of Thoracic Surgery, Rohrbach Hospital, Heidelberg, FRG.

We retrospectively analysed 301 patients with diffuse malignant pleural mesothelioma (235 male, 66 female; median age 59 years). Prognosis depended significantly on patient age, evidence of pain, loss of weight, tumour cell type, stage, local and distant metastasis, involvement of peritoneum and surgical treatment. The overall median survival rate was 238 days, after extended pleuropneumonectomy 284 days, and after decortication 315 days - significantly better than the prognosis in patients without surgical treatment or exploratory thoracotomy. Pleuropneumonectomy should only be considered in young patients with an epithelial cell-type tumour (possibly with adjuvant chemotherapy). Decortication seems nowadays to be the treatment of choice.


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Copyright © 1991 European Association for Cardio-Thoracic Surgery. Published by Elsevier. All rights reserved.