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European Journal of Cardio-Thoracic Surgery, Vol 6, 311-317, Copyright © 1992 by European Association for Cardio-thoracic Surgery

ARTICLES

Enoximone in newborns with refractory postoperative low-output states (LOS)

G Hausdorf, N Friedel, F Berdjis, HA Dieterich, JJ Fell, HT Dressler, A Werneyer, R Hetzer and PE Lange
German Heart Center, Berlin.

Enoximone was administered to 16 newborns with postoperative, catecholamine-refractory cardiac low-output states in addition to high- dose catecholamine treatment. Haemodynamic changes were assessed at baseline and during treatment. Haemodynamic parameters were improved in 12 newborns ("responders"), 9 of these survived. Three responders died; one from cardiac low-output and 2 from uncorrectable congenital heart disease verified by autopsy. Four newborns did not respond to enoximone therapy ("non-responders") and died. The haemodynamic effects of enoximone were characterized by an increase in cardiac index (+160%, P less than 0.0008), and a fall in right (-26%, P less than 0.0004) and left (-34%, P less than 0.003) atrial pressures. It is concluded that enoximone can be an effective agent in the treatment of cardiac low- output states refractory to high-dose catecholamines in neonates up to 7 months old.

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