HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Beyer, M. Articles by Hannekum, A. Search for Related Content PubMed PubMed Citation Articles by Beyer, M. Articles by Hannekum, A.

European Journal of Cardio-Thoracic Surgery, Vol 8, 557-562, Copyright © 1994 by European Association for Cardio-thoracic Surgery

ARTICLES

Indirect myocardial revascularization--an experimental study in the dog

M Beyer, U Beyer, S Mierdl, J Sirch, H von Behren and A Hannekum
Department of Cardiac Surgery, University of Ulm Hospital, Germany.

It has been shown in previous studies that grafting a free skeletal muscle flap onto the heart of the dog produces myocardial revascularization. In order to evaluate the functional aspect of these neovessels, an Ameroid constrictor was implanted into the LADs (left anterior descending coronary artery) of five dogs. At the same time, the free muscle flap was grafted onto the anterior wall of the heart. The arterial anastomosis was achieved with the internal mammary artery. Venous flow was drained into the right atrium. About 12 months later, the regional myocardial blood flow was evaluated adopting the radioactive microsphere technique. This was carried out with the LAD occluded by the Ameroid constrictor and the circumflex artery (CX) open (control conditions). Then the CX was occluded in order to exclude collateral blood flow. Afterwards another occlusion of the CX was performed ("preconditioning") to produce maximal opening of the anatomical collaterals. It was found that regional myocardial blood flow was unchanged in the antero-lateral parts of the hearts despite complete occlusion of the coronaries supplying this area. In the parts supplied by the CX, though, flow was minimal. "Preconditioning" positively influenced the perfusion of this region only in the epicardial parts. Histologically large sinusoid-like blood conductors connected the graft and the heart. Thus, grafting a free skeletal muscle flap onto the heart in the dog produces functional myocardial revascularization in the dog.

This article has been cited by other articles:

				S. C. Krämer, J. Görich, M. Beyer, E. Merkle, J. Gerber, N. Rilinger, R. Sokiranski, and H.-J. Brambs CT and Arteriography in the Evaluation of Indirect Myocardial Revascularization with a Free-Muscle Transplant: Initial Experience Radiology, July 1, 2000; 216(1): 123 - 127. [Abstract] [Full Text]

				M. Beyer, H. Hoffer, U. Beyer, and A. Hannekum Myocardial Revascularization with a Free Skeletal Muscle Flap: First Clinical Case Vascular and Endovascular Surgery, November 1, 1996; 30(6): 537 - 543. [Abstract] [PDF]