European Journal of Cardio-Thoracic Surgery, Vol 8, 635-638, Copyright © 1994 by European Association for Cardio-thoracic Surgery
Reinfusion potassium blood cardioplegia versus cold blood reinfusion alone in elective revascularization
P Peigh, A Fiore, K Naunheim, G Kaiser, DG Pennington, L McBride, V Willman and H Barner
Division of Cardiothoracic Surgery, St. Louis University Medical Center, MO 63110-0250.
The purpose of this study was to determine if the addition of potassium to
reinfusion cold blood cardioplegia (CBC) offers an advantage over cold
blood alone. Forty patients matched for age, left ventricular function,
extent of coronary disease and number of vessels bypassed were
prospectively randomized. Each patient received an initial dose of CBC (10
cc/kg) with potassium. Group I patients (n = 23) received subsequent
infusions of CBC (5 cc/kg) containing potassium while Group II patients (n
= 17) received cold blood only. The cross-clamp time, mean infusate volume
and temperature were not significantly different in the two groups.
Following reperfusion, the cardiac index and the CPK isoenzyme release at
0.5, 1, 8, and 12 h after cross-clamp release were not significantly
different between the groups. The postoperative appearance of new Q-waves,
inotropic agent requirement, and reversal of the lactate dehydrogenase
(LDH) isoenzyme ratio were also not significantly different in the two
groups. The study demonstrated that following initial arrest with
potassium, cold blood is equally as effective as potassium blood
cardioplegia in protecting the ischemic myocardium.