HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cangemi, V. Articles by Piat, G. Search for Related Content PubMed PubMed Citation Articles by Cangemi, V. Articles by Piat, G.

European Journal of Cardio-Thoracic Surgery, Vol 9, 473-478, Copyright © 1995 by European Association for Cardio-thoracic Surgery

ARTICLES

Local and/or distant recurrences in T1-2/N0-1 non-small cell lung cancer

V Cangemi, P Volpino, N D'Andrea, M Puopolo, S Fabrizi, MT Lonardo and G Piat
1st Department of Surgery, University of Rome, La Sapienza, Italy.

Data from a series of 181 patients subjected to long-term follow-up after surgical resection for non-small cell stage I and II lung cancer were analyzed to evaluate the statistical incidence and the prognostic factors of recurrence. The recurrence rate/year was particularly high in the first 2 years after surgery: the 2-year recurrence rate was 35.1% in stage I tumors and 51.8% in stage II, whereas the 5- and 7- year recurrence rates were 46.1 and 55.9% and 65.8 and 70.7%, respectively, for the same groups. Recurrences were observed more frequently in non-epidermoid carcinomas with multiple nodules (100% at 5 years) and in carcinomas classified as stage II (70.7% at 5-7 years), particularly when defined as adenocarcinoma (100% at 3 years). In the overall recurrence rate we observed no significant difference dependent on the type of resection even though limited segmental or wedge resection appeared to be related to a higher risk rate (true recurrence rate ratio: 0.6). Over two-thirds of the first observed recurrences were located at a distant site, with a slightly higher incidence of non- epidermoid carcinoma (72.5%). Isolated local recurrence mostly occurred in epidermoid carcinoma (47.6%). The most frequent sites of recurrence were the brain, bone and mediastinum. On multivariate analysis, independently significant adverse prognostic factors regarding the recurrence incidence were: tumor size greater than 3 cm, bronchial or hilar lymph node involvement, tumor histologically defined as adenocarcinoma, and the presence of satellite nodules.

This article has been cited by other articles:

				R. J. Korst, A. L. Kansler, J. L. Port, P. C. Lee, and N. K. Altorki Accuracy of surveillance computed tomography in detecting recurrent or new primary lung cancer in patients with completely resected lung cancer. Ann. Thorac. Surg., September 1, 2006; 82(3): 1009 - 1015. [Abstract] [Full Text] [PDF]

				B. A. Williams, H. Sugimura, C. Endo, F. C. Nichols, S. D. Cassivi, M. S. Allen, P. C. Pairolero, C. Deschamps, and P. Yang Predicting Postrecurrence Survival Among Completely Resected Nonsmall-Cell Lung Cancer Patients. Ann. Thorac. Surg., March 1, 2006; 81(3): 1021 - 1027. [Abstract] [Full Text] [PDF]

				M. K. Ferguson and A. G. Lehman Sleeve lobectomy or pneumonectomy: optimal management strategy using decision analysis techniques Ann. Thorac. Surg., December 1, 2003; 76(6): 1782 - 1788. [Abstract] [Full Text] [PDF]

				P. H. Hollaus, P. N. Wurnig, and N. S. Pridun The natural history of recurrence after bronchoplastic procedures for non-small cell lung cancer Ann. Thorac. Surg., August 1, 2003; 76(2): 363 - 369. [Abstract] [Full Text] [PDF]

				P. Granone, L. Trodella, S. Margaritora, A. Cesario, G. M. Corbo, G. Mantini, M. Balducci, and G. Fumagalli Radiotherapy versus follow-up in the treatment of pathological stage Ia and Ib non-small cell lung cancer. Early stopped analysis of a randomized controlled study Eur. J. Cardiothorac. Surg., October 1, 2000; 18(4): 418 - 424. [Abstract] [Full Text] [PDF]

				J. H. Park, Y. M. Shim, H. J. Baek, M.-S. Kim, D. H. Choe, K.-J. Cho, C.-T. Lee, and J. I. Zo Postoperative adjuvant therapy for stage II non-small-cell lung cancer Ann. Thorac. Surg., November 1, 1999; 68(5): 1821 - 1826. [Abstract] [Full Text] [PDF]

				J. J. Lafitte, M. E. Ribet, B. M. Prevost, B. H. Gosselin, M.-C. Copin, and A. H. Brichet Postresection Irradiation for T2 N0 M0 Non-Small Cell Carcinoma: A Prospective, Randomized Study Ann. Thorac. Surg., September 1, 1996; 62(3): 830 - 834. [Abstract] [Full Text]