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Eur J Cardiothorac Surg 2003;23:199-200
© 2003 Elsevier Science NL

Editorial Comment

^a The Yorkshire Laser Centre, Goole and District Hospital, Woodland Avenue, Goole, East Yorkshire DN14 6RX, UK
^b Postgraduate School of Medicine, The University of Hull, Hull, UK

Received 27 November 2002; accepted 27 November 2002.

^* Corresponding author. Tel./fax: +44-1724-290456.
e-mail: kmoghissi@yorkshirelasercentre.org

Key Words: Telomerase • Lung cancer • Bronchial lavage

The first 20% of the full text of this article appears below.

Detection of telomerase activity in bronchial lavage as an adjunct to cytological diagnosis in lung cancer
In the early years of the 20th century surgical resection, which was the standard form of treatment for most tumours, could not be applied to lung cancer due to the pneumothorax issue [1]. With this problem solved, surgical intervention became the treatment of choice at least since 1933 when the first pneumonectomy for cancer was performed [2]. One of the most significant advances in surgical therapy for lung cancer was the realisation in the 1950s that resectability did not equate with operability and that a selection process should operate in order, not only to reduce the number of thoracotomies which failed to offer successful resection but also to improve survival. This led to the establishment of oncologically based patient selection criteria for operation and monitoring of outcome and reliance on TNM classification. Progress in genetic and molecular biological research over the past 10–15 years is gradually shifting the emphasis from cyto/histopathological analysis to a more molecular based methodology for diagnosis and prognosis. It is now generally agreed that lung carcinogenesis is a multistep process and that genetic alternations precede morphological and cyto/histological changes. In recent . . . [Full Text of this Article]

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Detection of telomerase activity in bronchial lavage as an adjunct to cytological diagnosis in lung cancer

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