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Eur J Cardiothorac Surg 2006;30:568-569
© 2006 Elsevier Science NL

Letter to the Editor

Systemic oxidative stress associated with lung resection during single lung ventilation

^a Department of Anesthesiology, Weill Medical College of Cornell University, Memorial Sloan-Kettering Cancer Center, 525 East 68th Street, Lasdon 2, Box 50, New York, NY 10021, United States
^b Department of Pharmacology, Weill Medical College of Cornell University, 525 East 68th Street, Lasdon 2, Box 50, New York, NY 10021, United States
^c Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, United States

Received 21 April 2006; accepted 29 May 2006.

^_* Corresponding author. Tel.: +1 212 746 2701; fax: +1 212 746 8316. (Email: pmheerd@mail.med.cornell.edu).

Key Words: Oxidative stress • Lobectomy • eNOS • Tetrahydrobiopterin

The first 20% of the full text of this article appears below.

We read with interest the recent report from Misthos et al. [1] describing the relationship between oxidative stress and cardiopulmonary complications following lung resection. These investigators [2] as well as others [3] have previously linked the intentional collapse and subsequent re-expansion of the operative lung with increased plasma and urinary levels of malondialdehyde (MDA), a stable non-specific marker of lipid peroxidation by free radicals. Of particular note in the recent report was the increased incidence of pulmonary hypertension in patients that had undergone intentional lung collapse for 120 min. Although the methods for quantification of changes in pulmonary arterial pressure . . . [Full Text of this Article]