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Letters to the Editor

Matrix metalloproteinases do not properly work as peripheral blood biomarkers without taking into account the preanalytical impact of blood sampling

Department of Urology, University Hospital Charité, Schumannstrasse 20/21, D-10117 Berlin, Germany

Received 23 December 2007; accepted 13 February 2008.

^_* Corresponding author. Tel.: +49 30 450 515041; fax: +49 30 450 515904. (Email: klaus.jung@charite.de).

Key Words: Matrix metalloproteinases • Blood sampling procedure

The first 20% of the full text of this article appears below.

I read with great interest the article by Aharinejad et al. [1]. The authors measured matrix metalloproteinases (MMP) 1, 8, and 9 and tissue inhibitor of metalloproteases 1 (TIMP-1) in the serum of heart transplant recipients during the first year after cardiac transplantation at different time intervals. The changed serum concentrations of these analytes following cardiac transplantation were interpreted as possible consequences of allograft damage due to ischemia–reperfusion injury or acute and chronic rejections, respectively. However, the aim of this Letter to the Editor is to address the attention of the reader on a basic . . . [Full Text of this Article]

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