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Letters to the Editor

Reply to Sakurai. Brain injury in cardiopulmonary bypass surgery

^a Department of Surgery, University of California at San Diego, San Diego, CA, USA
^b The Children's Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, Philadelphia, PA, USA
^c Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia, PA, USA

Received 4 June 2009; accepted 5 June 2009.

^_* Corresponding author. Address: Division of Cardiovascular Surgery, University of California, San Diego, Rady Children's Hospital, 3030 Children's Way, Suite 202, San Diego, CA 92123, USA. Tel.: +1 858 966 8030; fax: +1 858 966 8032. (Email: ppastuszko@rchsd.org).

Key Words: Alpha-stat • Apoptosis • Cardiopulmonary bypass • Circulatory arrest • Oxygen • pH-stat

The first 20% of the full text of this article appears below.

The authors thank Dr Sakurai for his comments [1] concerning their study.

It has long been recognised that survivors of heart surgery involving deep hypothermic cardiac arrest (DHCA) face a variety of central nervous system deficits and the identification of neuroprotective strategies that would guard the brain from the negative sequelae of DHCA is therefore of great importance. To test for the protection of the brain we have made a rather deliberate decision to measure the critical regulators of programmed cell death by using the Western blot analysis. The accumulating evidence indicates that the increased expression of Bcl-2 provides protection against apoptosis and ischaemic . . . [Full Text of this Article]