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Eur J Cardiothorac Surg 2000;17:88
© 2000 Elsevier Science NL

Letter to the Editor

In vivo model for reversal of pulmonary blood flow in canines

Theodosios Dosios

University of Athens, School of Medicine, 2 Chatzigianni Mexi Str., 11528 Athens, Greece

Tel.: +30-1-724-7000; fax: +30-1-779-1456

I read with interest the article of Abramov et al. [1] entitled ‘In vivo model for reversal of pulmonary blood flow in canines’. The authors state that their ‘experiment shows that reversed pulmonary circulation can maintain life in a canine model’.

I would like to mention that Keith et al. [2] reversed the pulmonary circulation of the left lower lobe in dogs in 1962 and Reed [3] reversed the pulmonary circulation of the entire right canine lung in 1965. Reed reported that one animal survived 3.5 months after total reversal of pulmonary circulation (RPC) of the right lung and died 5 days following ligation of the left pulmonary artery. My colleagues and I [4] reversed the entire pulmonary circulation of both lungs in dogs. Three animals survived 20–70 h following RPC of the second lung. We found that ‘the pathological changes in the lung after RPC are not incompatible with life’ and concluded that RPC ‘affords a new experimental model for in vivo study of pulmonary pathophysiology’.

References

  1. Abramov D., Orlov B., Abramov Y. In vivo model for reversal of pulmonary blood flow in canines. Eur J Cardio-thorac Surg 1999;16:251-252.
  2. Keith H.B., Taques W.F., Cambell G.S. Retrograde and forward perfusion of intact dog lungs. Surg Forum 1962;3:145-146.
  3. Reed W.A. Reversal of pulmonary blood flow in the dog. J Thorac Cardiovasc Surg 1965;49:834-839.[Medline]
  4. Dosios T.J., Thevoz F., Fisher D.L., Adatepe M.H., Merkow L.P., Magovern G.J. Reversal of pulmonary circulation. J Thorac Cardiovasc Surg 1975;70:229-236.[Abstract]
Received September 27, 1999; accepted November 9, 1999.





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