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Eur J Cardiothorac Surg 2002;22:345-351
© 2002 Elsevier Science NL

Massive hemoptysis: what place for medical and surgical treatment

^a Department of Thoracic Surgery, Haut-Lévêque Hospital, Bordeaux University Hospital, avenue de Magellan, 33604 Pessac, France
^b Department of Ear-Nose and Throat and cervico-facial surgery, General Hospital, University Hospital, 21033 Dijon, France
^c Department of Intensive Care Unit, Haut-Lévêque Hospital, Bordeaux University Hospital, avenue de Magellan, 33604 Pessac, France
^d Department of Radiology, Haut-Lévêque Hospital, Bordeaux University Hospital, Avenue de Magellan, 33604 Pessac, France

Received 30 January 2002; received in revised form 19 May 2002; accepted 23 May 2002.

* Corresponding author. Service de Chirurgie Thoracique, Hôpital du Haut-Lévêque, 33604, Pessac, France. Tel.: +33-556555009; fax: +33-556555021
e-mail: jacques.jougon{at}chu-bordeaux.fr

	Abstract

Top Abstract 1. Introduction 2. Patients and methods 3. Results 4. Discussion References

 
Objective: The objective of the study was to define timing of surgical treatment in management of massive hemoptysis. Methods: We performed a retrospective review of all patients admitted for massive hemoptysis in the intensive care unit of our thoracic surgery department. Treatment was managed according to the patient's status, the etiology of bleeding, the findings of bronchoscopy and computed tomographic scan. Therapeutic measures available were medical treatment, tracheal intubation (single or double lumen tube), interventional endoscopy, arterial embolisation and surgical treatment. Results: Between September 1996 and December 2001, 43 patients were treated (nine females and 34 males with mean age of 54 years, range from 32 to 79). The mean red cell blood transfusion per patient was 1.57 Units. The patients were classified into three groups: Group 1, 11 patients were operated on immediately close to the bleeding crise (five pneumonectomy and six lobectomy); Group 2, five patients for whom operation was delayed from the 7th to the 22nd day after cessation of bleeding (five lobectomy); Group 3, 27 patients were treated by non-surgical methods (medical treatment, endobronchial treatment, percutaneous embolisation). Fifteen patients underwent an arterial embolization, which was complete in 13 cases. Among the five patients of group 2, cessation of bleeding was obtained by bronchial embolisation in four cases. Considering the whole series, 10 (23%) patients died: three (19%) patients in group 1, zero in group 2, seven (26%) in group 3. In two patients who were suffering from tumor necrosis, hemoptysis relapsed leading to death. Conclusion: Emergency thoracotomy for massive hemoptysis is at high risk. In case of bleeding from the arterial bronchial vessels, embolization may enable to postpone surgery and operate secondarily. In case of bleeding from the pulmonary vessels (tumor necrosis), surgical treatment must be immediate. An algorithm for management is proposed.

Key Words: Hemoptysis • Respiratory distress • Bronchial carcinoma • Tuberculosis • Bronchectasis • Bronchial arteries

	1. Introduction

Top Abstract 1. Introduction 2. Patients and methods 3. Results 4. Discussion References

 
In the beginning of last century, hemoptysis was pathognomonic of advanced phtisis [1,2]. Nowadays, chronic inflammatory pulmonary diseases and lung cancer are the most frequent causes in our country [3,4]. For majority of the patients, blood spitting or blood present in the sputum constitutes a worrying symptom rarely taken lightly. Hemoptysis can be a ‘lucky’ symptom allowing diagnosis of small bronchial carcinoma. However, when it is massive, patient's life is threatened and emergency admission in intensive care unit must be achieved. The threat lies in asphyxiation by flooding of the tracheobronchial tree [5]. Before definitive treatment, the risk remains even after cessation of an episode of massive hemoptysis because relapses are unpredictable. It is a medical emergency associated with a 30–50% rate of mortality reported in the last 20 years [6]. The surgical treatment in the management of these patients has been reduced since the first report of bronchial artery embolization by Remy et al. [7]. A new multidisciplinary approach associating the intensive care physician, the endoscopic pneumologist, the radiologist and the thoracic surgeon enables to lower the death rate. In our department, the included intensive care unit is the major referral center intended to manage massive hemoptysis. In this multidisciplinary approach, the place of surgical treatment between medical treatment and bronchial artery embolization is not obvious. We retrospectively reviewed the files of 43 patients treated for massive hemoptysis in the last 4 years to try to answer to that question.

	2. Patients and methods

Top Abstract 1. Introduction 2. Patients and methods 3. Results 4. Discussion References

 
2.1. Selection of patients and management
We considered the hemoptysis massive when the patient's life was threatened at short term or, as commonly defined, the expectoration of 600 ml or more of blood over 24 h. All patients included in this study satisfied those criteria.

Patients' assessment was conducted using the same procedure but was guided by seriousness of the situation. The main objectives of treatment were to prevent asphyxiation, to localize the site of bleeding, to stop the hemorrhage, to determine the etiology of hemoptysis, and to avoid the recurrence of hemoptysis definitively. Therapeutic means used were: pulmonary isolation, surgical treatment, interventional bronchoscopy, arterial embolization, and medical therapy. Those means were adapted to the cause of the hemoptysis, which was supposed by the past medical history and clinical examination of the patient, and confirmed by chest X-ray, bronchial endoscopy and computed tomography (CT) scan. Medical treatment included rest in bed, insertion of a wide-bore intravenous cannula, monitoring of arterial blood gases, aerosoltherapy of adrenaline, adapted antibiotic therapy if needed, and correction of clotting disorder if associated. An intravenous infusion of vasopressin (20 units over 15 min continued by 0.2 units/min for 36 h) was prescribed in the absence of contra-indication. Baseline hematology, biochemistry, and clotting test were obtained. Collected sputa were stained for bacteria, acid-fast bacilli and fungi. A chest X-ray was the first morphologic examination performed. A bronchial endoscopy was subsequently done. Its objective was threefold: to see the cause of bleeding if possible; to localize the site of bleeding; and to carry out endobronchial control measures [8]. These consisted in adrenaline serum lavage (adrenaline–saline solution 1) and laser YAG electrocotery. A CT-scan was then achieved. It was always performed in case of arterial embolisation or surgical treatment. When an arterial embolisation was achieved, infusion of vasopressine was carried on until the arteriography. Arterial embolisation was routinely performed by a Seldinger technique through femoral access. An emergency surgical treatment was applied when the site of bleeding was localized, the indication of pulmonary resection justified and the other means of treatment having failed. The surgical treatment was postponed as far as possible after cessation of bleeding using the other means of treatment. It was only considered when the patient had sufficient pulmonary reserve and when the bleeding source was clearly identified. When the surgical treatment was not possible (leak pulmonary function or diffuse lesions), the patient was informed about the possible recurrence of hemoptysis even after a successful arterial embolisation [8,9]. In case of massive acute bleeding, isolation of the bleeding lung from the healthy one was achieved by the use of a double lumen endotracheal tube. In that case, the choice between operation or non-surgical treatment was taken after the CT-scan.

2.2. Population
Between September 1996 and December 2001, 43 patients with massive hemoptysis were treated in the intensive care unit of the thoracic surgery department. There were 34 men and nine women aged 32–79 years (mean 54). All of them underwent a bronchoscopy and a CT scan. The causes of hemoptysis (Fig. 1 ) were chronic pulmonary inflammatory diseases in 28 cases (bronchiectasis 12 cases, tuberculosis sequelae four cases, atypic mycobacteriosis one case, aspergillosis one case, unknown etiologies 10 cases), lung cancer in 12 cases, necrotizing pneumonia in three cases. Additional factors to bleeding included loss of anticoagulant control in six patients (coumarinic in four cases and ticlopidine in two cases). Blood transfusions were achieved in 21 patients (1–6 units of red blood cell, mean 1.57 unit per patient). According to the treatment applied, patients were classified in three groups:

View larger version (18K): [in this window] [in a new window]   Fig. 1. Cause of massive hemoptysis and in-hospital mortality.

In two cases (case # 4 and # 8), bleeding was stopped, but operation was nevertheless immediately achieved to avoid fatal recurrence of hemoptysis coming from the pulmonary artery: In case # 8, the patient had been treated since 4 months for a cavitating asymptomatic lesion (Fig. 2 ) suspected to be sequella of tuberculosis. A bronchial arterial embolisation was attempted. As it was normal embolisation was not performed, but a pulmonary angiography showed that bleeding was coming from the left pulmonary artery (Fig. 3 ) ulcerated. The patient was immediately operated as it was a lung cancer. Cause of bleeding and type of operation performed are presented in Table 1, part A.

View larger version (116K): [in this window] [in a new window]   Fig. 2. CT scan showing a cavitating lesion against the pulmonary artery (star). In the corner, the bronchial arteriogram shows a normal left bronchial artery.

View larger version (143K): [in this window] [in a new window]   Fig. 3. Pulmonary angiography showing a false aneurysm of the pulmonary artery (arrow).

2.2.3. Group 3: non-surgical treatment
A non-surgical treatment was achieved in 27 cases. Those patients had either too diffused lesions or too weak cardiopulmonary function to undergo a surgical treatment. All of them received the medical treatment described above associated with local therapy or arterial embolisation.

Local therapy (adrenaline serum lavage) was applied during bronchoscopy when pulmonary isolation was not necessary. Laser electrocoagulation was achieved in one case of inoperable lung cancer recurring after medical treatment.

Arterial embolisation was attempted in 11 cases but successfully achieved in nine cases leading to cessation of bleeding: In one case the vasoocclusion was not completely achieved because of arising of an anterior spinal artery; the other case, above described (case # 8), bronchial arteries were normal (Fig. 2).

	3. Results

Top Abstract 1. Introduction 2. Patients and methods 3. Results 4. Discussion References

 
Altogether, 16 patients were operated (group 1 and group 2), out of which four were embolised before being secondarily operated. The other patients were treated by others non-surgical methods. None of the patients who underwent arterial embolisation alone or surgical treatment had recurrent hemoptysis at the time of follow-up extended from 3 months to 4 years (mean 1080 days). The hospital mortality was 23% (ten patients) in all the series. The mortality rate group wise was 27% (three patients) in group 1, zero in group 2, and 26% (seven patients) in group 3; by type of treatment applied it was: 19% (three patients) after surgical treatment and 26% (seven patients) after non-surgical treatment.

Two patients who suffered from a necrotic lung cancer died from a cataclysmic relapse hemoptysis. In one case, it was an inoperable central bronchial carcinoma in the course of radiotherapy, and in the second the patient suffered from an operable necrotic lung cancer. Medical treatment was applied and operation was planned the day after. A cataclysmic massive relapse led to the patient' death before the operation in spite of an immediate selective intubation.

One patient died from acute arrhythmia attributed to an overflow of intravenous glypressin. Other deaths were consecutive to bacterial pneumonia and acute respiratory distress syndrome.

	4. Discussion

Top Abstract 1. Introduction 2. Patients and methods 3. Results 4. Discussion References

 
Blood flooding into the tracheobronchial tree may arise from two vascular networks spreading into the pulmonary tissue: the bronchial and the pulmonary arterial systems. Bleeding coming from the former, results from neovascularisation of the lung systemic vessels, which quite often is induced by an inflammatory pulmonary disease or defect of the pulmonary arterial system [10]. Many inflammatory pulmonary diseases are able to produce such neovascularisation: bronchiectasis, suppurative lung disease, mycobacteriosis... Blood irruption stems from an erosion or a breaking of this hypertrophic neovascularisation. These vessels are endowed with a mural musculature wall, which is able to contract (arteriolar smooth muscle). Vasospasm of this network may be produced either by pharmacological methods (vasoactive drug as vasopressin or aerosolized adrenalin) or by physical methods (bronchial ice-cold saline lavage) able to produce temporary slowing or cessation of the bleeding.

Percutaneous embolisation is also a reliable method to eliminate this hypertrophic neovascularisation [4,5,7]. However, results are not stable and relapses are possible if the underlying disease responsible for promotion of neovascularisation is not removed [8,9]. None of the patients in our series treated by arterial embolisation without surgery had relapses. It is therefore, a temporary treatment, which stops acute bleeding in order to prepare the patient to a delayed surgery if indicated. Absence of tracheobronchial hemorrhage allows for safe operative intervention, with better delineation of the pulmonary disease and selection for the best economic pulmonary resection. Operation during bleeding crises may indeed precipitate emergency pneumonectomy. It is also better to operate once the bronchial tree has been effectively cleared and the pulmonary parenchymal and pulmonary vasculature reserve recovered. This explains the difference of death between group 1 (27%) and 2 (no death). Nevertheless, this difference is not statistically significant due to the number of patients included in the series.

Unlike bronchial vessels network, the pulmonary arterial one is not able to vasospam as powerfully as bronchial vessels. The wall of these vessels is thin and there is no active contraction. Vasoactive drugs or physical agents as ice-cold saline lavage have mild effects. Bleeding from these vessels generally comes through an ulceration of the vascular wall caused by destructive processes of the lung whatever the pathogenesis could be, such as, for instance, necrotizing bacterial pneumonia, necrotizing lung cancer, or aspergillus cavitazing infection. In such cases, the arrest of bleeding is due to a temporary sealing of the vascular tear by a clot. Smelting of the clot or progression of the vascular tear leads to relapse of an even more massive and usually fatal hemoptysis: this concerned two patients in our series. So, in case of bleeding coming from the pulmonary vessels, operation, if possible, must be performed immediately without any need of bronchial arteriography. Unfortunately, selection of the patients in one of the two categories, that is bronchial or pulmonary bleeding, is not always so easy. However, some clues may predict the pulmonary artery vessels origin: fungal ball, lung abscess, presence of a cavity with emptying and refilling aspect (Figs. 4 and 5 ), cavity with an air–fluid level as defined by Thoms et al. [11] are predicting element. Without clues of pulmonary artery bleeding, a bronchial arteriography is indicated. It will be completed by a pulmonary angiography in case of normal arteriography.

View larger version (127K): [in this window] [in a new window]   Fig. 4. Emptying and refilling mass. Chest X ray of the same patient as Fig. 5 performed before a hemoptysis crise (arrows, filled mass).

View larger version (123K): [in this window] [in a new window]   Fig. 5. Emptying and refilling mass. Chest X ray of the same patient as Fig. 4 performed after a hemoptysis crise (arrow).

Surgical treatment is best performed in postponing date in case of bronchial vessels hemorrhage. In case of pulmonary vessels hemorrhage, the operation must be achieved immediately. Similarly, in case of massive bleeding requiring pulmonary isolation, immediate operation must be performed in case of localized lesion. This attitude is summarized in Fig. 6 . Physiological lung exclusion may be an alternative technique [12] in case of dense vascular adhesion and pleural fibrosis, but, according to our experience, elective pulmonary resection is the optimal treatment, which was always possible in our series.

View larger version (19K): [in this window] [in a new window]   Fig. 6. Algorithm of management for massive hemoptysis.

	Footnotes

	References

Top Abstract 1. Introduction 2. Patients and methods 3. Results 4. Discussion References

 

1. Pursel S.E., Lindskog G.E. Hemoptysis. A clinical evaluation of 105 patients examined consecutively on a thoracic surgical service. Am Rev Respir Dis 1961;84:329-336.[Medline]
2. Eloesser L. Observations on sources of pulmonary hemorrhage and attempts at its control. J Thorac Surg 1938;7:671-679.
3. Conlan A.A., Hurwitz S.S., Krige L., Nicolau N., Pool M.B. Massive hemoptysis. Review of 123 cases. J Thorac Cardiovasc Surg 1983;85:120-124.[Abstract]
4. Lee T.W., Wan S., Choy D.K., Chan M., Arifi A., Yim A.P. Management of massive hemoptysis : a single institution experience. Ann Thorac Cardiovasc Surg 2000;6:232-235.[Medline]
5. Jean-Baptiste E. Clinical assessment and management of massive hemoptysis. Crit Care Med 2000;28:1642-1647.[Medline]
6. Knott-craig C.J., Oostuizen J.G., Rossouw G., Joubert J.R., Barnard P.M. Management and prognosis of massive hemoptysis. Recent experience with 120 patients. J Thorac Cardiovasc Surg 1993;105:394-397.[Abstract]
7. Rémy J., Arnaud A., Fardou H., Giraud R., Voisin C. Treatment of hemoptysis by embolisation of bronchial arteries. Radiology 1977;122:33-37.[Abstract]
8. Saumench J., Escarrabill J., Padro L., Montana J., Clariana A., Canto A. Value of fiberoptic bronchoscopy and angiography for diagnosis of the bleeding site in hemoptysis. Ann Thorac Surg 1989;48:272-274.[Abstract]
9. Mal H., Rullon I., Mellot F., Brugière O., Sleiman C., Menu Y., Fournier M. Immediate and long-term results of bronchial artery embolisation for life threatening hemoptysis. Chest 1999;115:996-1001.[Abstract/Free Full Text]
10. Haworth S.G., De Leval M., Macartney F.J. How the left lung is perfused after ligating the left pulmonary artery in the pig at birth: clinical implications for the hypoperfused lung. Cardiovasc Dis 1981;15:214-226.
11. Thoms N.W., Wilson R.F., Puro H.E., Arbulu A. Life-threatening hemoptysis in primary lung abscess. Ann Thorac Surg 1972;14:347.[Medline]
12. Dhaliwal R.S., Saxena P., Puri D., Sidhu K.S. Role of physiological lung exclusion in difficult lung resections for massive hemoptysis and other problems. Eur J Cardiothorac Surg 2001;20:25-29.[Abstract/Free Full Text]

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