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Eur J Cardiothorac Surg 2002;22:1035
© 2002 Elsevier Science NL

Letter to the Editor

Composite graft using the gastroepiploic artery, regarding the study design

Hitoshi Hirose*, Atsushi Amano

Department of Cardiovascular Surgery, Cleveland Clinic Foundation and Juntendo University Hospital, 9500 Euclid Avenue, Cleveland, OH 44195, USA

Received 1 August 2002; accepted 4 September 2002.

* Corresponding author. Cardiovascular Surgery, Cleveland Clinic Foundation, F25, 9500 Euclid Avenue, Cleveland, OH, 44195 USA. Tel.: +1-216-445-6816; fax: +1-216-707-9446
e-mail: genex{at}nifty.com

Key Words: Radial artery • Gastroepiploic artery • Vasospasm

I read with great interest the paper on randomized study of composite grafting of the radial artery (RA) versus gastroepiploic artery (GEA) by Dr Santos [1]. I have several questions about this randomized study.

As Dr Santos stated in the paper, the GEA is known to be a very fragile graft, prone to vasospasm. We recently published our series on GEA grafting [2], although we used the GEA as an in situ graft, our patency rate within 1 year after surgery was 97.1%, and the stenosis-free patency rate was 88.9%. The early stenosis rate of the GEA was 8.2%, which was much higher than the other grafts, and some of these stenoses were related to spasm.

Dr Santos demonstrated that the early angiographic patency rate of GEA was 68.9%, and some of the graft occlusions were related to spasm. The number of occlusions was, for me, unacceptably high. Although the authors did not mention their saphenous vein patency rate, I assume their GEA patency rate may be significantly lower than that of the saphenous vein graft. The vasospasm of the GEA was already mentioned in another paper [3], and the use of the free GEA was not recommended due to the high frequency of vasospasm [4].

Another issue regarding this paper is that the percentages of the patients with diabetes were relatively low (20.0% in the GEA group and 26.7% in the RA group) and that the age of the study group was relatively young (56.0 in the GEA group and 55.7 in the RA group). From my point of view, these particular patients (non-diabetic and young patients) have optimal benefit from bilateral internal mammary artery (IMA) bypass grafting, since patients receiving bilateral IMAs have a lower risk of remote cardiac event rates [5].

I also could not understand why the study patients received composite grafts, which is a technically demanding procedure in a vasospastic conduit. Composite grafting is usually reserved for patients with severe atherosclerosis in the ascending aorta. In addition, nowadays, these patients undergo off-pump coronary artery bypass graftin (CABG), which can be performed without touching the aorta and minimizes the risk of postoperative stroke. However, Dr Santos performed all these cases under cardiopulmonary bypass, disregarding the advantage of composite grafting. I also cannot agree with the routine composite grafting of the GEA with the IMA, unless someone presented good graft patency with composite GEA grafting.

Dr Santos stated that Ethical Research Committee agreed to this trial based on their preliminary data (patency rates of 96% of the RA and 88% of the GEA). However, they did not mention how many patients underwent angiography for the preliminary data, or how many of the patients received the composite grafts. I understood that all studied patients consented prior to the randomization, but I cannot agree to their study protocol: Why was the GEA used for composite grafting even though the preliminary data suggested a lower patency rate for the GEA than the RA? Why did the patients undergo on-pump bypass? Why did the patients not receive bilateral internal mammary artery grafting? Also, why did their internal review committee give permission for proceeding with this trial.

References

  1. Santos G.G., Stolf N.A.G., Moreira L.F.P., Haddad V.L.S., Simoes R.M.C., Carvallo S.R.V., Salgado A.A., Avear S.F., Jr Randomized comparative study of radial artery and right gastroepiploic artery in composite arterial graft for CABG. Eur J Cardio-thorac Surg 2002;21:1009-1014.[Abstract/Free Full Text]
  2. Hirose H., Amano A., Takanashi S., Takahashi A. Coronary artery bypass grafting using the gastroepiploic artery: 1000 cases. Ann Thorac Surg 2002;73:1371-1379.[Abstract/Free Full Text]
  3. van Son J.A., Smedts F., Vincent J.G., van Lier H.J., Kubat K. Comparative anatomic studies of various arterial conduits for myocardial revascularization. J Thorac Cardiovasc Surg 1990;99:703-707.[Abstract]
  4. Suma H., Amano A., Horii T., Kigawa I., Fukuda S., Wanibuchi Y. Gastroepiploic artery graft in 400 patients. Eur J Cardio-thorac Surg 1996;10:6-10.[Abstract]
  5. Lytle B.W., Blackstone E.H., Loop F.D., Houghtaling P.L., Arnold J.H., Akhrass R., McCarthy P.M., Cosgrove D.M. Two internal thoracic artery grafts are better than one. J Thorac Cardiovasc Surg 1999;117:855-872.[Abstract/Free Full Text]




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