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Eur J Cardiothorac Surg 2004;25:135-136
© 2004 Elsevier Science NL

Images in cardio-thoracic surgery

Mediastinal Castleman disease with calcific deposits

Dimitrios Mikroulisa, Kosmas Tsakiridisa, Vasiliki Kaloutsib, Vassilios Didilisa*

a Department of Cardiothoracic Surgery, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, P.C. 68100, Greece
b Department of Pathology, Aristotle University of Thessaloniki, Thessaloniki, Greece

Received 15 July 2003; received in revised form 31 July 2003; accepted 6 August 2003.

* Corresponding author. Tel.: +30-2-551-074166; fax: +30-2-551-074164
e-mail: vdidilis{at}med.duth.gr

Key Words: Castleman disease • Mediastinal tumor • Calcification • Computer tomography • Castleman disease • Mediastinal tumor • Calcification • Computer tomography

A 42-year-old woman underwent thoracotomy for an asymptomatic calcified tumor of the upper mediastinum. Histopathological examination proved Castleman disease, which is an unusual condition of unknown cause, consisting of massive proliferation of lymphoid tissue. Three histologic variants (hyaline-vascular, plasma-cell, and mixed) and two clinical types (localized and multicentric) of Castleman's disease have been described. The case presented here belongs to the localized type and can be cured by surgical removal. Calcification can occasionally be identified in Castleman disease and it might be an indicator of chronicity (Figs. 1 and 2) .



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  		Fig. 1. CT images with scattered irregular calcification sites of an upper mediastinum tumor.

 


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  		Fig. 2. The tumor, after removal, with dimensions 7.5x5.5x5 cm that was proven to be Castleman disease, hyaline vascular type (H and E, 400x).

 




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