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Eur J Cardiothorac Surg 2004;26:157
© 2004 Elsevier Science NL

Editorial comment

Pulmonary preservation with LPD and Celsior solution in porcine lung transplantation after 24 h of cold ischemia

Stephen R. Large*

Department Cardiothoracic Surgery, Papworth Hospital NHS Trust, Papworth Everard, Cambridge CB3 8RE, UK

* Corresponding author
e-mail: stephen.large{at}papworth.nhs.uk

This is an interesting, carefully controlled animal study comparing two crystalloid solutions for lung preservation. Storage times have been taken to an extreme (24 h) and perfusion following storage to 7 h. Interestingly, one animal died in each group each exhibiting ‘re-perfusion injury’. This aside we are given a body of evidence suggesting that Celsior (originally constituted for heart preservation) is superior to LPD. I would suggest that further work is required on two accounts, (1) to support this observation and (2) to tease out a mechanism. Phillipe Menasche planned his Celsior solution to promote anaerobic metabolism during the anoxic period. It may well be that preservation of energy stores is as important in lung transplantation as it is in preservation of the myocardium. I would be very pleased to see comparisons of Celsior lung preservation against our own preferred colloid and prostaglandin based method. This work from Hanover is a constructive step towards obtaining a reliable and effective lung preservation strategy.


Related Article

Pulmonary preservation with LPD and celsior solution in porcine lung transplantation after 24 h of cold ischemia
Sebastian P. Sommer, Gregor Warnecke, Jens M. Hohlfeld, Bernhard Gohrbandt, Jost Niedermeyer, Theodoros Kofidis, Axel Haverich, and Martin Strüber
Eur. J. Cardiothorac. Surg. 2004 26: 151-157. [Abstract] [Full Text] [PDF]



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[Abstract] [Full Text] [PDF]

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