EJCTS Click here for details of sales representative
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Hendrick B. Barner
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barner, H. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barner, H. B.
Related Collections
Right arrow Cardiac - pharmacology
Right arrow Cardiac - physiology

Eur J Cardiothorac Surg 2005;27:726
© 2005 Elsevier Science NL

Letter to the Editor

Internal thoracic artery response to papaverine: takes time

Hendrick B. Barner*

Department of Surgery, Forest Park Hospital, 6125 Clayton Ave., Suite 401, St Louis, MO 63136, USA

Received 2 December 2004; accepted 4 January 2005.

* Tel.: +1 314 768 3334; fax: +1 314 768 3462. (E-mail: hendrick.barner{at}tenethealth.com).

Key Words: Internal thoracic artery • Papaverine • Vasodilation

Takeuchi and associates found that exposure of the internal thoracic artery to intralumenal papaverine for 1min did not increase free flow [1]. It is well known that maximal vasodilation to papaverine requires at least 10min of exposure [2] so that their comparison is unfair and should be appropriately qualified.

It is also germane that papaverine inhibits cyclic nucleotide phosphodiesterase although it is not established that this is the mechanism for vasodilation [3].

It has been my practice for 30 years to treat all arterial conduits with intraluminal papaverine in heparanized blood (2mg/ml) to achieve a maximally dilated conduit at the time of graft placement. Diluting the papaverine in blood results in a pH of 7.3 because of the buffering capacity of blood [4].

References

  1. Takeuchi K, Sakamoto S, Nagayoshi Y, Nishizawa H, Matsubara J. Reactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting. Eur J Cardiothorac Surg 2004;26:956-959.[Abstract/Free Full Text]
  2. He G-W, Yang C-Q. Use of verapamil and nitroglycerin solution in preparation of radial Artery for Coronary Grafting. Ann Thorac Surg 1996;61:610-614.[Abstract/Free Full Text]
  3. Needleman P, Johnson EM. Vasodilators and the treatment of angina. In: Gilman AG, Goodman LS, Gilman A, editors. The pharmacologic basis of therapeutics. New York: Macmillan Publishing Co. Inc.; 1980. pp. 830.
  4. Laiken ND, Fanestil DD. Acid–base balance and regulation of H+ excretion. In: West JB, editor. Best and Taylor's physiologic basis of medical practice. Baltimore: Williams and Wilkins; 1985. pp. 286.




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Hendrick B. Barner
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barner, H. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barner, H. B.
Related Collections
Right arrow Cardiac - pharmacology
Right arrow Cardiac - physiology

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS