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Eur J Cardiothorac Surg 2005;28:909-910
© 2005 Elsevier Science NL

Letters to the Editor

Reply to Mishra

Matthias Siepe a , * , Friedhelm Beyersdorf a , Philippe Menasché b

a University Hospital Freiburg, Department for Cardiovascular Surgery, Hugstetter Str. 55, D-79106 Freiburg, Germany
b Department for Cardiovascular Surgery, Hospital E.G. Pompidou, Paris, France

Received 30 August 2005; accepted 31 August 2005.

* Corresponding author. Tel.: +49 761 270 2818; fax: +49 761 270 2550. (Email: matthias.siepe{at}web.de).

Key Words: Cell transplantation • Bone marrow-derived stem cells • Skeletal myoblast • Clinical trials

We appreciate Dr Mishra's comments [1] and fully agree with his conclusions. Indeed, from the time the initial results with skeletal myoblast transplantation were reported, we have always been concerned to be very cautious about data interpretation and have repeatedly stressed that many issues, most of which are appropriately listed by Dr Mishra, remained to be addressed and that only randomized controlled studies would allow to generate clinically meaningful conclusions. Some advocates of bone marrow stem cell transplantation have occasionally been more aggressive by claiming that these cells featured a true regeneration potential [2]. Now, it is increasingly recognized that many of these statements were often based on weak methodologies and that it is, just as for myoblasts or other cell types, premature to draw definite conclusions pertaining to the ability of cell therapy to rebuild new myocardium under clinically relevant conditions [3]. The review we have just published [4] intended primarily to update practising surgeons with respect to a rapidly evolving field of research and certainly not to provide naively overenthusiastic claims which remain premature and inappropriate as long as the current reverse "bedside to bench" move has not generated more robust basic data about the benefits, optimal modalities of use and limitations of cell therapy.

References

  1. Mishra PK. Stem cell therapy for myocardial regeneration: creating hype ignoring reality. Eur J Cardiothorac Surg 2005;28:912.[Free Full Text]
  2. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-705.[CrossRef][Medline]
  3. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, Pasumarthi KB, Virag JI, Bartelmez SH, Poppa V, Bradford G, Dowell JD, Williams DA, Field LJ. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004;428:664-668.[CrossRef][Medline]
  4. Siepe M, Heilmann C, von Samson P, Menasché P, Beyersdorf F. Stem cell research and cell transplantation for myocardial regeneration. Eur J Cardiothorac Surg 2005;28:318-324.[Abstract/Free Full Text]




This Article
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Friedhelm Beyersdorf
Philippe Menasché
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Right arrow Articles by Siepe, M.
Right arrow Articles by Menasché, P.
Related Collections
Right arrow Cardiac - other
Right arrow Coronary disease
Right arrow Molecular biology

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