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Eur J Cardiothorac Surg 2007;31:879-887. doi:10.1016/j.ejcts.2007.02.014
Copyright © 2007, European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved
Departments of Cardiothoracic Surgery and Anatomy, Leiden University Medical Center, Leiden, The Netherlands
Received 5 September 2006; received in revised form 1 February 2007; accepted 2 February 2007.
* Corresponding author. Address: Department of Cardiothoracic Surgery D6-26, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Tel.: +31 71 5262348; fax: +31 71 5248110. (Email: m.g.hazekamp{at}lumc.nl).
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Abstract |
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 Top Abstract 1. Introduction2. Materials and methods3. Results4. DiscussionAppendix AReferences |
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Key Words: Transposition great arteries • Pulmonary stenosis • Arterial switch operation • Nikaidoh operation • Rastelli operation • REV operation
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1. Introduction |
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TopAbstract1. Introduction2. Materials and methods3. Results4. DiscussionAppendix AReferences |
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A bicuspid and obstructive pulmonary valve is sometimes amenable to valve repair after which an arterial switch operation (ASO) may offer a good solution [1,2]. Valvular stenosis by fused commissures in a bicuspid pulmonary valve can be treated by valvotomy in the same way as in a stenotic bicuspid aortic valve and should not be considered an absolute contraindication for an ASO.
Also, subpulmonary obstructive tissue can many times be resected allowing for an ASO [1,3]. Subpulmonary stenosis in the form of a fibrous ridge or membrane can be enucleated, while posteriorly deviated septal muscle can usually be resected. In case of a hypoplastic pulmonary annulus or non-resectable LVOTO, an ASO is impossible. Repair can be performed by different procedures: the Rastelli procedure, the Réparation à l’Etage Ventriculaire (REV) operation, the Metras modification, or the operations that were described by Bex and Nikaidoh. An atrial rerouting procedure (Senning/Mustard) may be an option depending on the degree of pulmonary stenosis that will remain. A LV-to-pulmonary artery (PA) conduit has been described but is not a desirable option [1,3–12].
The anatomy usually allows for biventricular repair, but in some hearts only univentricular palliation is possible. Straddling of the tricuspid valve, or, especially, of the mitral valve, may prohibit ventricular septation.
We describe a series of cardiac specimens with transposition of the great arteries (TGA) and LVOT obstruction, either with or without VSD. The method of sequential segmental analysis and description of all associated anomalies was used for this purpose. After careful and detailed description of the specimens, we aim to evaluate the different surgical options in each specimen. Pros and cons of the different procedures are analyzed and reported in relation to the specific anatomy of each specimen.
The anatomical details of many of the specimens in this study have been described previously [13–16]. However, new surgical techniques have been developed since, and we aim to analyze the anatomical details of the specimens in relation with the current surgical techniques.
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2. Materials and methods |
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TopAbstract1. Introduction2. Materials and methods3. Results4. DiscussionAppendix AReferences |
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2.1 Anatomical criteria
The Leiden collection comprises more than 2500 specimens with congenital cardiac anomalies, most of which have not been operated. From the 200 specimens with TGA we have selected 33 specimens with TGA and important LVOTO. Hearts with other-than-concordant atrioventricular connections, specimens with importantly unbalanced ventricles, and specimens with double outlet right ventricle (RV) were excluded from this study. DORV hearts were not included as DORV was considered as forming a too heterogeneous group of diagnoses for the purpose of this study. An exception was made for two specimens (3646, 4538) with TGA and subpulmonary VSD that showed overriding of the pulmonary artery (Taussig–Bing malformation with LVOTO). Specimens in which surgery had changed the anatomy severely were also excluded. For these reasons, not all specimens that are mentioned in earlier publications were selected for this study; on the contrary, some more recent heart specimens have been added [13–16].
2.2 Surgical criteria
Several considerations were used for this purpose. Generally speaking, if an ASO was possible this was considered to be the best choice. Resection of LVOTO and/or repair of a stenotic pulmonary valve were considered if these procedures would allow for an ASO (±VSD closure) without remaining serious LVOTO and without risk of early pulmonary (neo-aortic) valve replacement [1–3]. The Nikaidoh operation was preferred over REV, Metras and Rastelli procedures. REV and Metras procedures were preferred over the Rastelli operation [7]. The procedure of aortic translocation that was originally described by Bex et al. can be considered as being a good alternative to the Nikaidoh procedure; the Bex procedure can be used in patients with TGA and LVOTO with intact septum. In the description by Bex the outlet septum was not resected and the first reported patient had no VSD [5]. Relief of LVOTO can be adequately performed through the pulmonary valve, but full resection of the outlet septum may, in some instances, be the only way to completely desobstruct the LVOT. Leaving the RV in the systemic circulation (after an atrial switch procedure) was judged to be less optimal. An atrial switch procedure with a LV-to-PA conduit was thought to be an undesirable choice. Orthotopic placement of a RV-to-PA connection or conduit (as in the Nikaidoh procedure) was preferred over an extracardiac positioned RV-to-PA conduit (as in the Rastelli procedure), which always includes a right ventriculotomy [4,6,7,8]. A direct LV-to-aorta connection was considered to be better than an oblique or angulated tunnel between LV and aorta. Special attention was given to a possible decrease in volume and function of the RV after surgical repair. Procedures that would lead to a diminished RV volume were considered as being not optimal. Positional anomalies of the atrioventricular valves were in some instances considered to be an important obstacle to septation and biventricular repair. Finally, it was assumed that the coronary anatomy would never form an obstacle for either an ASO or a posterior translocation of the aorta.
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3. Results |
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TopAbstract1. Introduction2. Materials and methods3. Results4. DiscussionAppendix AReferences |
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3.1.1 TGA/IVS/LVOTO
Four pulmonary valves were bicuspid, and LVOTO was caused by a fibrous ridge or tunnel (four), obstructive muscular conus (two), bulging of septal muscle (four), or anterior malattachment or malrotation of the mitral valve (one). Discontinuity of the mitral and the pulmonary valve resulted in subpulmonary muscular conus and was responsible for different degrees of LVOT obstruction. The presence of an ALM bundle was responsible for obstructive bulging of muscular tissue in six specimens. Combinations of obstructive anatomic substrates were frequent (Table 1
).
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3.1.4 Position great arteries/coronary anatomy (TGA/IVS and TGA/VSD)
The position of the great arteries was as follows: aorta right anterior to the pulmonary artery in 18, aorta side by side to the pulmonary artery in 8, aorta directly anterior in 4, aorta right posterior in 2, and aorta left anterior to the pulmonary artery in 1 specimen (with associated dextrocardia). The coronary anatomy was classified according to the Leiden classification [15]. 1LCx-2R was found in 17 specimens, 1L-2CxR was observed in 5, 1RL-2Cx in 6, and 1R-2LCx in 4 hearts. One specimen presented with a single coronary ostium (2LCxR). A double LAD system was present in three hearts. All but one heart with 1LCx-2R or 1L-2CxR coronary anatomy had the aorta anterior or right anterior to the pulmonary artery. In one specimen with 1LCx-2R anatomy and dextrocardia the aorta was positioned left anteriorly to the pulmonary artery. In all hearts with 1RL-2Cx or 1R-2LCx anatomy the aorta was either positioned side by side or right posteriorly to the pulmonary artery (Tables 1 and 2).
3.2 Surgery
3.2.1 TGA/IVS/LVOTO
In all but one heart with TGA/IVS an ASO was considered to be possible. All four bicuspid pulmonary valves were judged to perform well after an ASO: no or minimal insufficiency and no or minimal obstruction. In two bicuspid valves a limited commissurotomy was considered necessary to optimize valve function.
Discrete fibrous ridges were detected in four specimens and could all easily be resected. An anterolateral muscle (muscle of Moulaert) was found in two specimens and occurred in association with obstructive subpulmonary muscular conus [17]. In both hearts resection of the obstruction through the pulmonary valve was considered to be possible, supposedly resulting in an unobstructed LVOT.
In one specimen LVOTO was caused by an anteriorly rotated mitral valve that was not repairable. An ASO (or a Bex procedure) would have resulted in unacceptable LVOTO. However, an atrial switch procedure (Senning or Mustard) with resection of the obstructive accessory fibrous tissue would result in some RVOT obstruction that was judged to be acceptable. The alternative would have been univentricular palliation.
3.2.2 TGA/VSD/LVOTO
In 10 specimens an ASO with VSD closure and LVOTO resection was judged feasible. Accessory fibrous tissue attached to the mitral valve presented in two specimens and could be resected resulting in an unobstructed LVOT (Fig. 1
). In one specimen LVOTO was caused by an aneurysmatic membranous septum protruding into the LVOT. This aneurysmatic tissue could be resected or tightened. In six hearts resection of obstructive muscular tissue was deemed necessary for relief of LVOTO. Obstruction by malalignment of the outlet septum was present in three of these specimens. Resection of (part of) the outlet septum would lead to an unobstructed LVOT. Resection could always be performed through the pulmonary valve.
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In the two hearts with Taussig–Bing anomaly the subaortic RVOT was also considered as being (potentially) narrow. To prevent later RVOT obstruction part of the outlet septum and muscle bundles from outlet septum to the anterior RV free wall would need to be resected.
In another nine hearts with TGA/VSD and LVOTO biventricular repair was possible, but pulmonary valve hypoplasia and/or non-resectable subpulmonary obstruction restricted the use of an ASO.
In these specimens the surgical options were either Rastelli/REV procedure or Nikaidoh operation. In two specimens Rastelli or REV procedures were not possible while a Nikaidoh operation was judged to be technically feasible with good outcome. Anterior rotation of the mitral valve inhibited creation of a LV-to-aorta tunnel but after resection of the obstructive pulmonary valve and the complete outlet septum the aorta could be detached and moved posteriorly on top of the LVOT. The anomalous position of the mitral valve would not result in LVOTO. In the second specimen extension of the VSD into the inlet septum was considered to impair tunneling the LV to the aorta. The tunnel would obstruct the RV inlet (Fig. 2A and B). Therefore, a Nikaidoh procedure was judged to be the only technique to accomplish biventricular repair.
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In four specimens LVOTO could not be adequately relieved. In one specimen (6134) with anterior rotation of the mitral valve and anterior papillary muscle malattachment the LVOTO was considered to be sufficiently mild to perform an atrial switch operation with a RVOT gradient afterwards. Repositioning of the mitral valve was not possible, and the option of leaving the malpositioned mitral valve in the LVOT following an ASO was considered as undesirable. Univentricular management of the anomaly was considered to be the only option in three hearts with straddling atrioventricular valves. In one specimen (2915) with a tricuspid valve straddling through a big inlet VSD, septation was not possible, thus blocking the way to biventricular repair. In two other specimens (435, 884) the mitral valve straddled through a subpulmonary VSD. Septation was judged to be impossible and univentricular palliation would be the only choice (Fig. 4 ).
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4. Discussion |
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TopAbstract1. Introduction2. Materials and methods3. Results4. DiscussionAppendix AReferences |
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A discrete fibrous ridge in the LVOT is sometimes, although infrequently, observed in TGA/IVS. At the time of the ASO the fibrous ridge can easily be resected or enucleated. The presence of a fibrous ridge indicates an abnormal anatomy or flow profile of the LVOT and, similar to fibrous subaortic stenosis in normal hearts, there will be a chance of recurrence of this fibrous LVOTO even after successful enucleation [1,3]. A dynamic muscular LVOT obstruction can be present in TGA/IVS and will usually resolve after the ASO when the RV/LV pressure ratio is normalized [19]. In TGA there is normally a fibrous connection between the pulmonary and the mitral valve. In case of muscular conus the pulmonary and the mitral valves are separated by muscular tissue. An anterolateral muscle may be present and is typically located between the anterior leaflet of the mitral valve and the anteroseptal wall of the LV [17]. In these cases, the mitral valve may be positioned a little more posteriorly and slightly rotated [13]. In our series of TGA/IVS this was observed in specimens 5986 and 5540. An ALM can usually be resected through the pulmonary valve allowing for an unobstructed LVOT.
Thus, for TGA/IVS the risks of late dysfunction of the pulmonary valve and reoperation for LVOTO recurrence appear to be sufficiently low to consider an ASO with LVOTO resection/pulmonary valve repair as the best possible solution [1–3].
4.1.2 TGA/VSD/LVOTO
Deviation of the outlet septum always results in a malalignment VSD and to obstruction of usually the RVOT. In TGA, deviation of the outlet septum through the VSD may, however, lead to considerable obstruction of the LVOT situated either anterior to the pulmonary orifice or posterior as part of subpulmonary conus (Fig. 5
). Therefore, LVOTO is more frequent and usually more severe in TGA with VSD than it is in TGA/IVS.
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When the pulmonary valve is hypoplastic or when the LVOTO cannot be resected completely, the LV needs to be connected to the aorta to allow for biventricular repair. The VSD may have to be enlarged to create an unobstructed communication. VSD augmentation can be done by resecting the outlet septum, as has been described by Lecompte et al [6]. The VSD can also be enlarged by resection of part of the trabecular septum in the postero-inferior corner of the VSD. To facilitate a LV-to-aorta connection the VSD must, at least, have some relation to the aorta. Inlet septal defects or more apically located muscular VSDs are generally not suitable for the Rastelli or REV procedures. In our specimens we found that six times both a Nikaidoh operation and a Rastelli/REV operation could be performed. However, two times a Nikaidoh procedure was the only way to construct a biventricular heart: a Rastelli procedure could not be performed because of malposition of the mitral valve or because of extension of the VSD into the inlet septum (Fig. 2A and B). In the six specimens where both Nikaidoh and Rastelli procedures were possible, we observed five times that significant RV volume reduction after the Rastelli procedure would occur (Fig. 3). It can be postulated that a REV operation in some of these hearts would result in slightly less RV volume reduction as the VSD patch can be made somewhat straighter than in the Rastelli procedure [7].
When comparing the procedures, the theoretical advantages of the Bex–Nikaidoh procedure or posterior translocation of the aorta are obvious: no volume reduction of the RV, an ‘anatomical’ connection of LV to aorta, orthotopic placement of the RV-to-PA conduit, and no right ventriculotomy. Aortic translocation is the only technique that permits biventricular repair in case of inlet or distant muscular VSD, straddling mitral or tricuspid valve, or an already small RV. The detachment of the aortic root from the RV and resection of the outlet septum permit an optimal exposure for ventricular septation, which can be especially helpful in the presence of malpositioned or straddling atrioventricular valves. In the procedure that was described first by Bex et al., the posterior aortic translocation was not combined with resection of the outlet septum and re-septation by a patch as was described by Nikaidoh et al. [5,9]. The original Bex procedure is probably a good solution for patients with TGA and LVOTO with a small VSD or with intact septum as long as the LVOTO can be desobstructed fully through the pulmonary valve.
The Bex and the Nikaidoh procedures are technically more demanding and involve the risks associated with coronary transfer and aortic valve detachment and reinsertion. We have assumed for the purpose of this study that coronary artery transfer would never pose a problem, neither for an arterial switch procedure nor for a Bex or a Nikaidoh operation. However, some coronary artery anatomies may increase the risk of coronary artery transfer. Detachment of the aortic root from the right ventricle may be more hazardous with a right coronary artery springing from sinus 1 and running close to anterior part of the aortic root. Increasing experience with the arterial switch operation, the Ross and Konno operations provide the technical skills that are necessary for posterior aortic translocation [9–12].
Several authors have reported that the long-term results of the Rastelli procedure are not satisfactory. The incidence of late mortality is high as is the number of reoperations. Replacement of the extracardiac conduit is needed in almost all cases, and there appears to be an important incidence of reoperation for residual or recurrent LVOTO [20,21]. RV-to-PA homografts in extracardiac position have been reported to be less durable than homografts in an orthotopic pulmonary position [22]. For the abovementioned reasons, the Lecompte/Metras procedures and the Nikaidoh operations should probably be given priority over the classical Rastelli operation in many patients with TGA, VSD, and LVOTO.
Finally, in some hearts, univentricular palliation can be the only surgical option. Ventricular septation may not be possible because of straddling of the mitral or the tricuspid valve. Straddling valves do not always inhibit VSD closure: sometimes the straddling chords can be detached from the septum and reinserted after suturing the VSD patch. However, in the specimens we have examined this would either be impossible or very difficult as straddling chords could not be resected and reattached without severe damage to valvular function. Furthermore, we found a cleft anterior leaflet to be frequently associated with straddling mitral valve, which would have complicated valve reconstruction even more (Fig. 4). In another study of anatomical specimens, this not-so-infrequent association of TGA and mitral valve anomalies has been described earlier by Moene and Oppenheimer-Dekker [16]. Especially in the presence of LVOTO the anatomy of the mitral valve should therefore be exactly clarified before proceeding with surgical repair.
The limitation of this study is that the specimens form a selection that may not be fully representative for clinical practice. Furthermore, some degree of surgical subjectivity was unavoidable when deciding upon the best procedure for each specimen.
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Appendix A |
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TopAbstract1. Introduction2. Materials and methods3. Results4. DiscussionAppendix AReferences |
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Dr D. Metras (Marseille, France): We all know that a switch operation with a transposition and normal bicuspid valve is currently done. Now, you say that examining your specimens you could think that with the repair of unicommissural or bicuspid pulmonary valve, which probably is stenotic, you could do switch. Does that mean that presently if you find this situation you would do a switch operation?
Dr Hazekamp: Well, I did say that in the group with VSD we found a unicommissural pulmonary valve that was in the subgroup where the annulus of the pulmonary valve was very small and we had to do another option, a Nikaidoh, or Rastelli operation. So this was not amenable to arterial switch operation. And I think that a unicommissural pulmonary valve is not a good idea to do a switch operation.
Dr Metras: But even with a bicuspid with stenosis, you would do a switch operation?
Dr Hazekamp: Depending on the degree of valve abnormality. If a small valvotomy would be sufficient to relieve the problem, then probably we would go on with a switch operation.
Dr W. Mrowczynski (Poznan, Poland): I wanted to ask from which era do your specimens come from?
And what is the relation between the data you show and your real clinical life, I mean the spectrum of TGAs you encounter?
Dr Hazekamp: The specimens come from long time ago when the rate of autopsies was a lot higher than it is nowadays. So it's not representative for what we are doing in the clinic. So you should not make a relation between the clinical situation right away.
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Footnotes |
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References |
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TopAbstract1. Introduction2. Materials and methods3. Results4. DiscussionAppendix AReferences |
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This article has been cited by other articles:
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  V. O. Morell and P. D. Wearden Nikaidoh operation for transposition of the great arteries with a ventricular septal defect and pulmonary stenosis MMCTS, February 20, 2008; 2008(0220): 2337. [Abstract] [Full Text] [PDF]
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