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Eur J Cardiothorac Surg 2007;31:1147. doi:10.1016/j.ejcts.2007.03.011
Copyright © 2007, European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved


Letters to the Editor

Some reflections on talc poudrage

Thomas F. Molnara,*, Ramon Rami-Portab

a Department of Surgery, Medical School, University of Pécs, H-7632 Pécs, Ifjuság u 13, Hungary
b Thoracic Surgery Service, Hospital Mutua de Terassa, University of Barcelona, Spain

Received 12 January 2007; accepted 9 March 2007.

* Corresponding author. Tel.: +36 72 536 496; fax: +36 72 536 496. (Email: mft{at}iseb.pote.hu).

Key Words: Malignant pleural effusion • Talc pleurodesis • History

We read with interest the well researched article of Stefani et al. [1] about the different techniques of intrapleural talc.

This technical paper really filled the gap in our knowledge following established evidences of superiority of the talc itself [2,3] over other products.

We have a question and two comments. Could we be provided with data on the size of the talc particles? This intriguing question has its importance in the simple physical fact, that the size of contact surface of the individual particles and their absolute number are probably closely related to the mesothelial reaction created. One can expect, that the poudrage method with its carburettor like permeated cloud-like delivery creates highly homogenous dispersion of the talc particles. Some compare the endoscopic view to the snowfall. On the other hand, the degree of the dispersion in the slurry method depends largely on the time, patience and attention one pays while preparing the mixture. Therefore, while we have a properly standardised method on the poudrage arm, we need more information on the circumstances the slurry was delivered. Instead of disposable gas propelled atomiser one can use a puffer similar to those the beauty industry offers to deliver perfumes. One of us has memories from the early 1990s, when a metal cannister fitted with a rubber ball – called US Army model – was applied in the Frenchay Hospital, Bristol.

If somebody cannot afford disposable gas propelled atomiser there is another method to increase the degree of homogenisation of talc particules in the slurry. The idea is stolen from certain nail varnishes where a metal piece serves as homogenisator. Putting small calibre bearing balls into the slurry syringe makes the 1 min shaking more effective. Unfortunately enough, so far we were unable to convince the pharmaceutical industry the usefulness of a kit like this.

Finally, we think, that an article on the intrapleural use of talc [1] would not be complete without citing Norman Bethune, the brilliant Canadian lung surgeon, who pioneered the usage of talc [4]. He helped the sufferers in the Spanish Civil War regardless of their uniform, and was the first in organizing a mobile blood transfusion service [5]. He died literally while his last breath went for his patients in China, in 1939. Bethune's invention has been serving our patients since then, whose lives would be more miserable without his brilliant idea: the talc.

References

  1. Stefani A, Natali P, Casali C, Morandi U. Talc poudrage versus talc slurry in the treatment of malignant pleural effusion. A prospective comparative study. Eur J Cardiothorac Surg 2006;30:827-832.[Abstract/Free Full Text]
  2. Zimmer PV, Hill M, Casey K, Harvey E, Low DE. Prospective randomised trial of talc slurry versus bleomycin in pleurodesis for symptomatic malignant pleural effusion. Chest 1997;112:430-434.[Abstract/Free Full Text]
  3. Diacon ASH, Wyser C, Bolliger CT, Tamm M, Pless M, Perruchoud AP, Soler M. Prospective randomized comparison of thoracoscopic talc poudrage under local anesthesia versus bleomycin instillation for poleurodesis for malignant pleural effusions. Am J Respir Crit Care Med 2000;162:1445-1449.[Abstract/Free Full Text]
  4. Bethune N. Pleural poudrage. A new technique for the deliberate production of pleural adhesion as a preliminary to lobectomy. J Thorac Surg 1935;4:251-261.
  5. Broggi M. Memorias de un cirujano. Ediciones Peninsula, Barcelona, 2001.




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