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Eur J Cardiothorac Surg 2009;35:555. doi:10.1016/j.ejcts.2008.11.024
Copyright © 2009, European Association for Cardio-thoracic Surgery. Published by Elsevier. All rights reserved.
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Letters to the Editor

Reply to Katznelson et al. Tranexamic acid is safe with regard to vein graft patency

Joel Dunning*

Department of Cardiothoracic Surgery, James Cook University Hospital, Middlesbrough, UK

Received 17 November 2008; accepted 19 November 2008.

* Corresponding author. Tel.: +447801548122. (Email: joeldunning{at}doctors.org.uk).

Key Words: Coronary surgery • Aprotinin • Tranexamic acid

Thank you for alerting the EJCTS to this excellent paper [1,2]. Your paper used MRI scanning to show that the patency of vein grafts between 5 and 30 days after coronary surgery was 87% (231/265) in the placebo group and 85% (253/297) in patients who received 100 mg/kg of tranexamic acid after induction of anaesthesia. We are also aware that you used this important information in the creation of the BART trial [3], a landmark paper in the assessment of drug therapy to minimise bleeding after cardiac surgery. Your paper is available full-text for free currently from the Journal of Thoracic and Cardiovascular Surgery and I encourage readers to download it and read it in full including the optimal dosages of tranexamic acid for patients undergoing coronary surgery.

References

  1. Katznelson R, Djaiani GN, Karski J. Guideline on antiplatelet and anticoagulation management in cardiac surgery. Eur J Cardiothorac Surg 2009;35:555.[Free Full Text]
  2. Karski J, Djaiani G, Carroll J, Iwanochko M, Seneviratne P, Liu P, Kucharczyk W, Fedorko L, David T, Cheng D. Tranexamic acid and early saphenous vein graft patency in conventional coronary artery bypass graft surgery: a prospective randomized controlled clinical trial. J Thorac Cardiovasc Surg 2005;130(2):309-314.[Abstract/Free Full Text]
  3. Fergusson DA, Hébert PC, Mazer CD, Fremes S, MacAdams C, John M, Murkin JM, Teoh K, Duke PC, Arellano R, Blajchman MA, Bussières JS, Côté D, Karski J, Martineau R, Robblee JA, Rodger M, Wells G, Clinch J, Pretorius R, the BART Investigators A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. New Eng J Med 2008;358:2319-2331.[Abstract/Free Full Text]




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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Right arrow Email this article to a friend
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Right arrow Author home page(s):
Joel Dunning
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Google Scholar
Right arrow Articles by Dunning, J.
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PubMed
Right arrow Articles by Dunning, J.
Related Collections
Right arrow Cardiac - pharmacology
Right arrow Cardiac - other

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