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Eur J Cardiothorac Surg 2009;35:1116. doi:10.1016/j.ejcts.2009.02.026
Copyright © 2009, European Association for Cardio-thoracic Surgery. Published by Elsevier. All rights reserved.
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Letters to the Editor

Reply to Sadaba

Alan R. Conanta,*, Alec W.M. Simpsonb

a Department of Physiology, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, UK
b Department Human Anatomy & Cell Biology, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3GE, UK

Received 16 February 2009; accepted 18 February 2009.

* Corresponding author. Tel.: +44 151 7945510; fax: +44 151 7945517. (Email: conant{at}liv.ac.uk).

Key Words: Arteries • CABG arterial grafts • CABG pharmacology/physiology • Rho-kinase

We very much appreciate the comments by Sadaba [1] and he is correct to highlight the importance of the rho-kinase pathway. From the data presented in our paper [2] and that from earlier studies on the actions of phenoxybenzamine [3,4] it is clear that should an irreversible inhibitor of rho-kinase become available it would represent an ideal candidate for the topical treatment of arterial bypass grafts.

References

  1. Sadaba JR. Rho-kinase, the forgotten link?. Eur J Cardiothorac Surg 2009;35:1115.[Free Full Text]
  2. Shackcloth MJ, Conant AR, Thekkudan J, Ghotkar S, Simpson AWM, Dihmis WC. Attenuation of receptor-dependent and -independent vasoconstriction in the human radial artery. Eur J Cardiothorac Surg 2008;34:839-844.[Abstract/Free Full Text]
  3. Mussa S, Guzik TJ, Black E, Dipp MA, Channon KM, Taggart DP. Comparative efficacies and durations of action of phenoxybenzamine, verapamil/nitroglycerin solution, and papaverine as topical antispasmodics for radial artery coronary bypass grafting. J Thorac Cardiovasc Surg 2003;126:1798-1805.[Abstract/Free Full Text]
  4. Conant AR, Shackcloth MS, Oo AY, Chester MR, Simpson AWM, Dihmis WC. Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery—the effect of other vasodilators. J Thorac Cardiovasc Surg 2003;126:448-454.[Abstract/Free Full Text]




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Alan R. Conant
Right arrow Permission Requests
Google Scholar
Right arrow Articles by Conant, A. R.
Right arrow Articles by Simpson, A. W.M.
PubMed
Right arrow Articles by Conant, A. R.
Right arrow Articles by Simpson, A. W.M.
Related Collections
Right arrow Cardiac - pharmacology
Right arrow Coronary disease
Right arrow Great vessels

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